中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (29): 2693-2702.doi: 10.3969/j.issn.1673-5374.2013.29.001

• 原著:脑损伤修复保护与再生 •    下一篇

蛛网膜下腔出血大鼠脑组织突触小体相关蛋白25的表达

  

  • 收稿日期:2013-05-06 修回日期:2013-08-09 出版日期:2013-10-15 发布日期:2013-10-15
  • 基金资助:

    国家自然科学基金(No. 81171105, 81271300, 81100872) ，江苏省优秀医学学术领袖计划(NO. LJ201139)，国家十二五规划的国家关键技术研发计划(2011BAI08B0, 2011BAI08B06), 江苏省教育厅(No. 11KJB320011)，苏州教育局(No. SYS201109)

Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage

Gang Chen1, Tong Hu1, 2, Qi Li1, Jianke Li1, Yang Jia1, Zhong Wang1   

  1. 1 Department of Neurosurgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
    2 Department of Neurosurgery, Yixing People’s Hospital, Yixing 214200, Jiangsu Province, China
  • Received:2013-05-06 Revised:2013-08-09 Online:2013-10-15 Published:2013-10-15
  • Contact: Zhong Wang, M.D., Professor, Department of Neurosurgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China, nju_neurosurgery@ 163.com.
  • About author:Gang Chen, M.D., Attending physician.

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摘要：

已有研究证实，突触小体相关蛋白对突触功能和认知行为有重要调节作用。实验用视交叉池注血法建立具有空间学习障碍的蛛网膜下腔出血大鼠模型，应用western blot和免疫组织化学染色发现，蛛网膜下腔出血后1，3 d，大鼠颞叶皮质、海马、小脑的突触小体相关蛋白25表达降低较明显，结果验证，蛛网膜下腔出血大鼠脑组织突触小体相关蛋白25的表达下调。

关键词: 神经再生神经再生, 脑损伤, 突触小体相关蛋白25, 蛛网膜下腔出血, 认知, 皮质, 海马, 小脑, 基金资助文章脑损伤, 突触小体相关蛋白25, 蛛网膜下腔出血, 认知, 皮质, 海马, 小脑, 基金资助文章

Abstract:

Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that synaptosomal-associated protein-25 expression in the temporal lobe, hippocampus, and cerebellum significantly lower at days 1 and 3 following subarachnoid hemorrhage. Our findings indicate that synaptosomal-associated protein-25 expression was down-regulated in the rat brain after subarachnoid hemorrhage.

Key words:   neural regeneration, brain injury, synaptosomal-associated protein-25, subarachnoid hemorrhage, cognition, cortex, hippocampus, cerebellum, grants-supported paper, neuroregeneration