中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (29): 2763-2774.doi: 10.3969/j.issn.1673-5374.2013.29.008

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

视前区性两形核的发育及雌激素样复合物的影响

  

  • 收稿日期:2013-06-25 修回日期:2013-08-29 出版日期:2013-10-15 发布日期:2013-10-15

Development of the sexually dimorphic nucleus of the preoptic area and the influence of estrogen-like compounds

Zhen He1, 2, Sherry Ann Ferguson1, Li Cui2, Lazar John Greenfield2, Merle Gale Paule1   

  1. 1 Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    2 Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72005, USA
  • Received:2013-06-25 Revised:2013-08-29 Online:2013-10-15 Published:2013-10-15
  • Contact: Zhen He, M.D., Ph.D., Office Room 53D-203N, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, zhen.he@fda.hhs.gov.
  • Supported by:

    This study was supported by the National Center for Toxicological Research/FDA (Protocol P00710 to He Z and Protocol P00706 to Ferguson SA). Cui L was supported by UAMS Hornick Award to her and NIH Grant R01-NS049389 and UAMS institutional funds to Greenfield LJ.

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摘要：

动物大脑内明确的性两形性结构是性两形核，一群定位于海马视前区的细胞。应用常规Nissl染色或钙结合蛋白D28K免疫组化染色可显示啮齿动物视前区性两形核。将钙结合蛋白D28K阳性的神经细胞群区定义为视前区性两形核已得到越来越多的认可。视前区性两形核的性两形性的机制得到了广泛研究。最近研究显示，干细胞增殖和迁移可能在生后视前区性两形核发育有关键作用。性激素和雌激素样复合物可影响视前区性两形核的大小，但这种作用是否通过提高第三脑室干细胞巢中干细胞活力增大实现尚不明了。

关键词: 神经再生, 综述, 性取向, 性行为, 钙结合蛋白D28K, 雌激素, 环境因素, 双酚A, 神经干细胞, 基金资助文章

Abstract:

One of the well-defined sexually dimorphic structures in the brain is the sexually dimorphic nucleus, a cluster of cells located in the preoptic area of the hypothalamus. The rodent sexually dimorphic nucleus of the preoptic area can be delineated histologically using conventional Nissl staining or immunohistochemically using calbindin D28K immunoreactivity. There is increasing use of the calbindin D28K-delineated neural cluster to define the sexually dimorphic nucleus of the preoptic area in rodents. Several mechanisms are proposed to underlie the processes that contribute to the sexual dimorphism (size difference) of the sexually dimorphic nucleus of the preoptic area. Recent evidence indicates that stem cell activity, including proliferation and migration presumably from the 3rd ventricle stem cell niche, may play a critical role in the postnatal development of the sexually dimorphic nucleus of the preoptic area and its distinguishing sexually dimorphic feature: a signifi-cantly larger volume in males. Sex hormones and estrogen-like compounds can affect the size of the sexually dimorphic nucleus of the preoptic area. Despite considerable research, it remains un-clear whether estrogen-like compounds and/or sex hormones increase size of the sexually dimor-phic nucleus of the preoptic area via an increase in stem cell activity originating from the 3rd ventricle stem cell niche.

Key words: neural regeneration, review, sexual orientation, sexual behavior, calbindin D28K, estrogen-like compound, bisphenol A, neural stem cells, grants-supported paper, neuroregeneration