中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (2): 135-142.doi: 10.4103/1673-5374.125341

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

腰背痛静息态默认网络与岛叶的脑功能连接

  

  • 收稿日期:2013-10-27 出版日期:2014-01-10 发布日期:2014-01-10
  • 基金资助:

    广东省科技基金(NO. 2012B031800305)

Resting-state connectivity in the default mode network and insula during experimental low back pain

Shanshan Zhang1, Wen Wu1, Guozhi Huang1, Ziping Liu1, Shigui Guo1, Jianming Yang2, Kangling Wang1   

  1. 1 Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
    2 Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
  • Received:2013-10-27 Online:2014-01-10 Published:2014-01-10
  • Contact: Wen Wu, M.D., Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China, wuwen66@163.com.
  • Supported by:

    This study was supported by the Science and Technology Foundation of Guangdong Province of China, No. 2012B031800305.

摘要:

以往的功能磁共振成像研究表明,默认网络与痛觉的认知和记忆有关,岛叶在疼痛辨别与信息整合中具有重要作用,但默认网络与岛叶之间的疼痛相关功能连接尚不清楚。实验采用3.0 T磁共振成像仪对12例健康志愿者(24.8 ± 3.3岁)分别在非疼痛状态下与注射高渗盐水致腰背疼痛状态下进行静息态功能磁共振扫描,比较疼痛及非疼痛状态下静息态默认网络与岛叶的功能连接的差异。与正常状态相比,受试者腰背痛状态时双侧岛叶与前额叶中部、颞叶内侧皮质连接增高;双侧岛叶与后扣带回、楔前叶、顶下小叶连接减低;前扣带回与后岛叶的功能连接增强,而与前岛叶的功能连接减低。结果提示静息态下腰背痛被试者的默认网络与岛叶功能连接存在异常,这可能与疼痛刺激引起一系列认知与情绪功能的改变有关,提示了疼痛处理时各脑区之间相互作用的重要性。

关键词: 腰背痛, 静息态, 功能连接, 功能磁共振成像, 默认网络, 岛叶, 高渗盐水, 认知, 情感, 目测类比评分法

Abstract:

Functional magnetic resonance imaging studies have shown that the insular cortex has a significant role in pain identification and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the default mode network and insula during pain remain unclear. This study used 3.0 T functional magnetic resonance imaging scans in 12 healthy subjects aged 24.8 ± 3.3 years to compare the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the importance of the interaction between these regions in pain processing.

Key words: nerve regeneration, low back pain, resting-state, functional connectivity, functional magnetic resonance imaging, default mode network, insula, hypertonic saline, cognitive, emotion, visual analogue scale, the Science and Technology Foundation of Guangdong Province of China, neural regeneration