中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (3): 531-536.doi: 10.4103/1673-5374.293154

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

先天性失歌症者在大脑初级皮质感觉运动区域有变化

  

  • 出版日期:2021-03-15 发布日期:2020-12-17
  • 基金资助:

    中国国家自然科学基金项目（81771172，81671671）和湘雅二院启动基金

Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study

Jun-Jie Sun1, 2, Xue-Qun Pan3, Ru Yang1, Zhi-Shuai Jin4, Yi-Hui Li2, Jun Liu1, *, Da-Xing Wu4, *#br#   

  1. 1 Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China;  2 Department of Radiology, the Affiliated Zhuzhou Hospital of Xiangya College of Medicine, Central South University, Zhuzhou, Hunan Province, China;  3 Lister Hill National Center for Biomedical Communication, National Library of Medicine, Bethesda, MD, USA ;  4 Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China
  • Online:2021-03-15 Published:2020-12-17
  • Contact: Jun Liu, PhD, junliu123@csu.edu.cn; Da-Xing Wu, PhD, wudaxing2017@csu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81771172 (to DXW), 81671671 (to JL) and the Second Xiangya Hospital Start-Up Fund, China.

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摘要：

感知音调是人类听觉系统的核心功能之一，而先天性失歌症是一种音调感知的障碍。试验纳入了17例先天性失歌症者和14名健康对照者进行功能磁共振分析，使用基于体素的度中心性方法来识别功能网络异常性，以探索与先天性失歌症相关的神经网络和认知功能变化。结果发现与正常对照相比，先天性失歌症者右侧主要感觉运动区的度中心性明显下降，表示神经网络中相应大脑区域的中心性或效率下降，且度中心性和蒙特利尔失歌症测评量表得分呈正相关。结果首次发现了先天性失歌症患者在大脑初级感觉运动区域的神经系统改变，且先天性失歌障碍右侧主要感觉运动区记忆和音乐辨别中起重要作用。试验于2019年2月9日经中南大学湘雅二医院伦理委员会批准，批准号WDX20180101GZ01。

https://orcid.org/0000-0002-0344-4745 (Jun Liu); 

https://orcid.org/0000-0002-6786-8109 (Da-Xing Wu)

关键词: 先天性失歌症, 终身残疾, 度中心性, 局部功能连接, 初级感觉运动皮质, 初级感觉皮质, 初级运动皮质, 音乐感知, 基于体素的分析, 静息态

Abstract: Perceiving pitch is a central function of the human auditory system; congenital amusia is a disorder of pitch perception. The underlying neural mechanisms of congenital amusia have been actively discussed. However, little attention has been paid to the changes in the motor rain within congenital amusia. In this case-control study, 17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed. A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group. We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls, indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network. We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores. In conclusion, our study identified novel, hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia. Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination. The study was approved by the Ethics Committee of the Second Xiangya Hospital, Central South University, China (No. WDX20180101GZ01) on February 9, 2019.

Key words: congenital amusia, degree centrality, lifelong impairment, local functional connectivity, music discrimination, primary motor area, primary sensorimotor area, primary sensory area, resting-state functional magnetic resonance imaging, voxel-based analysis