中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (4): 362-376.doi: 10.4103/1673-5374.128237

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

基质金属蛋白酶的时间依赖融合:可指导轴突萌发和突触发生

  

  • 收稿日期:2014-01-08 出版日期:2014-02-25 发布日期:2014-02-25

Time dependent integration of matrix metalloproteinases and their targeted substrates directs axonal sprouting and synaptogenesis following central nervous system injury

Linda L. Phillips, Julie L. Chan, Adele E. Doperalski, Thomas M. Reeves   

  1. Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA
  • Received:2014-01-08 Online:2014-02-25 Published:2014-02-25
  • Contact: Linda L. Phillips, Department of Anatomy and Neurobiology Virginia Commonwealth University, P.O. Box 980709 Richmond, VA 23298, USA, llphilli@vcu.edu.

Abstract:

Over the past two decades, many investigators have reported how extracellular matrix molecules act to regulate neuroplasticity. The majority of these studies involve proteins which are targets of matrix metalloproteinases. Importantly, these enzyme/substrate interactions can regulate degenerative and regenerative phases of synaptic plasticity, directing axonal and dendritic reorganization after brain insult. The present review first summarizes literature support for the prominent role of matrix metalloproteinases during neuroregeneration, followed by a discussion of data contrasting adaptive and maladaptive neuroplasticity that reveals time-dependent metalloproteinase/substrate regulation of postinjury synaptic recovery. The potential for these enzymes to serve as therapeutic targets for enhanced neuroplasticity after brain injury is illustrated with experiments demonstrating that metalloproteinase inhibitors can alter adaptive and maladaptive outcome. Finally, the complexity of metalloproteinase role in reactive synaptogenesis is revealed in new studies showing how these enzymes interact with immune molecules to mediate cellular response in the local regenerative environment, and are regulated by novel binding partners in the brain extracellular matrix. Together, these different examples show the complexity with which metalloproteinases are integrated into the process of neuroregeneration, and point to a promising new angle for future studies exploring how to facilitate brain plasticity.

Key words: neuroregeneration, reactive synaptogenesis, matrix metalloproteinases, brain injury, adaptive and maladaptive neuroplasticity, metalloproteinase inhibition, osteopontin, lipocalin 2