中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (21): 1933-1938.doi: 10.4103/1673-5374.145365

• 综述:脑损伤修复保护与再生 • 上一篇    

尼莫地平神经保护效应的热点及未来趋势

  

  • 收稿日期:2014-10-16 出版日期:2014-11-15 发布日期:2014-11-15

Hot spots and future directions of research on the neuroprotective effects of nimodipine

Runhui Li   

  1. Department of Neurology, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China
  • Received:2014-10-16 Online:2014-11-15 Published:2014-11-15
  • Contact: Runhui Li, Department of Neurology, Affiliated Central Hospital of Shenyang Medical College, Shenyang 110024, Liaoning Province, China, Lirh710717@163.com

Abstract:

Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.

Key words: neuroprotection, nerve regeneration, nimodipine, ischemic cerebrovascular disease, Web of Science, CiteSpace, research fronts, development trends, scientific mapping, visualization