中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (23): 2111-2114.doi: 10.4103/1673-5374.147939

• 综述:周围神经损伤修复保护与再生 • 上一篇    

神经移位治疗臂丛神经损伤：提高大脑皮质可塑性

  

  • 收稿日期:2014-10-10 出版日期:2014-12-10 发布日期:2014-12-10
  • 基金资助:

    上海市卫生顶基金；上海市科技厅面上项目

Nerve transfer helps repair brachial plexus injury by increasing cerebral cortical plasticity

Guixin Sun 1, Zuopei Wu 1, Xinhong Wang 2, Xiaoxiao Tan 3, Yudong Gu 4   

  1. 1 Department of Trauma Surgery, East Hospital, Tongji University School of Medicine, Shanghai, China
    2 Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China
    3 Medical School of the University of Queensland, Brisbane, St. Lucia, Queensland, Austualia
    4 Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China
  • Received:2014-10-10 Online:2014-12-10 Published:2014-12-10
  • Contact: Yudong Gu, sunguixin@sina.com.
  • Supported by:

    This work was supported by grants from the General Project funded by Shanghai Municipal Health Bureau in China, No. 20124328, and the General Program funded by Shanghai Municipal Science and Technology Commission in China, No. 13ZR434100, and the National Natural Science Foundation of China, No. 81201468, and Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, No. 08D22270600.

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摘要：

在臂丛神经损伤的外科干预中常采用的方法是将一部分次要神经移位至重要神经，以最大恢复受区神经肌肉功能。比如将肋间神经移位至腋神经；将桡神经及其副神经移位至肩胛上神经，将膈神经移位至肌皮神经，将对侧C7神经移位至正中神经或桡神经等。神经移位已成为臂丛神经根性撕脱伤患者臂丛神经重建外科干预的主要手段。很多研究证实，神经移位治疗臂丛神经损伤后大脑皮质功能重组及可塑性提高和功能有了显著改善。文章综述了多种神经移位外科干预修复臂丛神经损伤的进展，以及神经移位对臂丛神经损伤患者大脑皮质可塑性的影响。

关键词: 神经再生, 臂丛神经损伤, 神经移位, 皮质可塑性, 肋间神经, 膈神经, 桡神经, 大脑功能重组, 综述

Abstract:

In the treatment of brachial plexus injury, nerves that are functionally less important are transferred onto the distal ends of damaged crucial nerves to help recover neuromuscular function in the target region. For example, intercostal nerves are transferred onto axillary nerves, and accessory nerves are transferred onto suprascapular nerves, the phrenic nerve is transferred onto the musculocutaneous nerves, and the contralateral C7 nerve is transferred onto the median or radial nerves. Nerve transfer has become a major method for reconstructing the brachial plexus after avulsion injury. Many experiments have shown that nerve transfers for treatment of brachial plexus injury can help reconstruct cerebral cortical function and increase cortical plasticity. In this review article, we summarize the recent progress in the use of diverse nerve transfer methods for the repair of brachial plexus injury, and we discuss the impact of nerve transfer on cerebral cortical plasticity after brachial plexus injury.

Key words: nerve regeneration, brachial plexus injury, nerve transfer, cortical plasticity, intercostal nerve, phrenic nerve, radial nerve, cerebral functional reconstruction, review, neural regeneration