中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (4): 631-635.doi: 10.4103/1673-5374.155439

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

基质金属蛋白酶9在颅内外动脉支架置入后3d高于正常值2.5倍:发生再狭窄及采取神经保护的干预靶标

  

  • 收稿日期:2015-02-09 出版日期:2015-04-22 发布日期:2015-04-22
  • 基金资助:

    福建省卫生系统优秀青年医生项目(2011-1-7)

Matrix metalloproteinase 9 level as an indicator for restenosis following cervical and intracranial angioplasty and stenting

Jun-peng Liu, Yin-zhou Wang, Yong-kun Li, Qiong Cheng, Zheng Zheng   

  1. Department of Neurology, Fujian Provincial Hospital, Provincial Clinical Department of Fujian Medical University, Fuzhou, Fujian Province, China
  • Received:2015-02-09 Online:2015-04-22 Published:2015-04-22
  • Contact: Yin-zhou Wang, M.D., Ph.D., wphd@163.com
  • Supported by:

    This study was supported by the Fund for Distinguished Young Doctors from Fujian      Provincial Health Department, No. 2011-1-7.

摘要:

颅内外动脉血管内支架置入是有效安全降低缺血性卒中风险的方法,但支架置入后支架内再狭窄是影响其疗效的一个重要因素。观察40例接受颅内外动脉支架置入患者血清基质金属蛋白酶9水平的变化预测再狭窄的风险。发现置入后3d血清基质金属蛋白酶9>正常参考值2.5倍的患者出现再狭窄的比率为30%(3/10),而<正常参考值2.5倍的患者未出现再狭窄。基质金属蛋白酶9>正常参考值持续>30 d的患者出现再狭窄的比率为12%(2/17),<30d的患者为4%(1/23),二者无明显差异(P>0.05)。故作者认为颅内外动脉血管内支架置入后3 d基质金属蛋白酶9>正常参考值2.5倍时,可作为预测再狭窄及采取有效神经保护措施的指标。

关键词: 神经再生, 基质金属蛋白酶9, 颅内外动脉支架, 再狭窄, 颅内动脉狭窄

Abstract:

Cervical and intracranial angioplasty and stenting is an effective and safe method of reducing the risk of ischemic stroke, but it may be affected by in-stent restenosis. The present study investigated serum level of matrix metalloproteinase 9 as a predictor of restenosis after 40 patients underwent cervical and/or intracranial angioplasty and stenting. Results showed that restenosis occurred in 30% (3/10) of patients when the serum level of matrix metalloproteinase 9 at 3 days after surgery was 2.5 times higher than preoperative level. No restenosis occurred when the serum level of matrix metalloproteinase 9 at 3 days after surgery was not 2.5 times higher than preoperative level. Restenosis occurred in 12% (2/17) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for more than 30 days after surgery, but only occurred in 4% (1/23) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for less than 30 days after surgery. However, the differences observed were not statistically significant (P > 0.05). Experimental findings indicate that when the serum level of matrix metalloproteinase 9 is 2.5 times higher than preoperative level at 3 days after cervical and intracranial angioplasty and stenting, it may serve as a predictor of in-stent restenosis

Key words: nerve regeneration, matrix metalloproteinase 9, cervical and intracranial angioplasty and stenting, restenosis, intracranial artery stenosis, neural regeneration