中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (10): 1570-1571.doi: 10.4103/1673-5374.167749

• 观点:退行性病与再生 • 上一篇    下一篇

髓鞘能量代谢对神经退行性病变的保护作用

  

  • 收稿日期:2015-09-11 出版日期:2015-10-28 发布日期:2015-10-28
  • 基金资助:

    “ Giuseppe Levi–Accademia Nazionale dei Lincei”基金 No.“Giuseppe Levi”_2013; Paolo’神经科学计划,No.2008.1142

     

Role of myelin sheath energy metabolism in neurodegenerative diseases

Silvia Ravera*, Isabella Panfoli   

  1. Pharmacy Department, Biochemistry Laboratory, University of Genova, Viale Benedetto XV, Genova, Italy
  • Received:2015-09-11 Online:2015-10-28 Published:2015-10-28
  • Contact: Silvia Ravera, Ph.D., silvia.ravera@gmail.com.
  • Supported by:

    This study was supported by: Grant from the “Fondazione Giuseppe Levi–Accademia Nazionale dei Lincei” for the research project entitled: “Produzione extramitocondriale di ATP in mielina: localizzazione dei complessi della catena respiratoria e possible ruolo nella degenerazione assonale in Sclerosi Multipla”, No. Borsa “Giuseppe Levi”_2013; Grant from the ‘‘Compagnia di San Paolo’’- Neuroscience Program, for the research project entitled: ‘‘Energetic metabolism in myelinated axon: a new trophic role of myelin sheath’’, No. 2008.1142.

摘要:

髓鞘中氧化ATP有着重要的作用,在健康的情况下,髓鞘产生ATP用以支持轴突的能量需求。与此相反,在病理条件下,髓鞘氧化磷酸化受损,导致轴突变性并增加氧化应激产量。作者认为,髓鞘的能量代谢对轴突有着举足轻重的作用,它的变化可以促进神经退行性病变的产生。这一设想可能会改变原有认为脱髓鞘疾病是由于轴突尚失而导致发病的观念,有助于开发个体化用以维持或恢复线粒体能量代谢的新疗法。

Abstract:

More than any other organs, brain energy demand is entirely dependent on glucose catabolism through the oxidative phosphorylation (OXPHOS). Glucose is the major cerebral energy substrate in the nervous system (NS). Ketone bodies can utilized as an additional substrate, but in any case, neurons critically depend on oxygen supply. This sounds quite surprising considering that NS contains few mitochondria, which are universally considered the exclusive site of OXPHOS.