中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1750-1751.doi: 10.4103/1673-5374.169613

• 观点:退行性病与再生 • 上一篇    下一篇

萝卜硫素抗甲基乙二醛细胞毒性:对抗神经退行性疾病的新途径?

  

  • 收稿日期:2015-08-12 出版日期:2015-12-07 发布日期:2015-12-07
  • 基金资助:

    该篇亮点文章部分由MIUR-FIRB(RBAP11HSZS项目)和蒙特博洛尼亚Ë拉文纳基金会(意大利)支持

Antiglycative activity of sulforaphane: a new avenue to counteract neurodegeneration?

Cristina Angeloni#, Marco Malaguti#, Silvana Hrelia*   

  1. Department for Life Quality Studies, Alma Mater Studiorum-
    University of Bologna, Bologna, Italy
  • Received:2015-08-12 Online:2015-12-07 Published:2015-12-07
  • Contact: Silvana Hrelia, Ph.D., silvana.hrelia@unibo.it.#These authors contributed equally to this work.
  • Supported by:

    All Authors contributed equally in writing and critically revising the paper. Part of the researches described in this highlight was supported by MIUR-FIRB (project RBAP11HSZS) and Fondazione del Monte di Bologna e Ravenna (ITALY). The authors certify that they have no affiliations with or involvement in any organization
    or entity with any financial or non-financial interest in the subject matter discussed in this paper.

摘要:

神经退行性变是大量附带“神经退行性疾病”标签的一个重要表现。神经退行性疾病帕金森病、阿尔茨海默病和亨廷顿病是导致中老年人群渐进性退变和/或神经细胞死亡和残疾的主要原因。目前这些疾病的发病率呈上升趋势,但有效疗法却很少。直到现在,还没有药物可以延缓阿尔茨海默病的进展,但营养药物化合物已逐渐成为预防/治疗该病的另一种途径。在这些营养产品当中,在十字花科蔬菜中发现的异硫氰酸酯莱菔硫烷(异硫氰酸根合-4-(甲基亚磺酰基)丁烷)(SF)因为在不同的体外、体外神经变性动物模型中表现的神经保护活性而受到相当大的关注。此外,SF在中枢神经系统中的生物利用度也得到了广泛的论证。

Abstract:

Neurodegeneration is a key aspect of a large number of diseases that come under the umbrella of “neurodegenerative diseases” with the most notable being Parkinson’s, Alzheimer’s, and Huntington’s disease. They are all incurable and debilitating conditions that result in progressive degeneration and/or death of nerve cells and are the leading cause of disability in the elderly. The incidence of these diseases is on the rise and yet there is a paucity of effective therapies to treat them. Research is now focused on understanding the mechanisms of disease in order to develop new therapies and strategies that may benefit patients suffering from any of the conditions. SF exerts pleiotropic actions on different cellular targets protecting neurons by cell death induced by MG exposure. SF action, in fact, could not be ascribed to a simple anti-glycative process, but, considering the “tandem” of free radical and MG and the fall in intracellular GSH concentration, it can modulate different cellular functions leading to a pro-survival frame of particular importance in the prevention/counteraction of multifactorial neurodegenerative diseases like AD.