中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (12): 1917-1918.doi: 10.4103/1673-5374.169626

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

果蝇胚胎轴突导向可以给神经再生带来什么?

  

  • 收稿日期:2015-09-25 出版日期:2015-12-30 发布日期:2015-12-30

What can Drosophila axonal development teach us about nerve regeneration?

Sofia J. Araújo*   

  1. Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, Barcelona, Spain
  • Received:2015-09-25 Online:2015-12-30 Published:2015-12-30
  • Contact: Sofia J. Araújo, Ph.D., sarbmc@ibmb.csic.es.
  • Supported by:

    This work was supported by Spanish Ministery of Science (MICINN RYC-2007-00417).

摘要:

胚胎发育期间,研究者们在确定细胞外线索和调解轴突导向受体方面已经取得了相当大的进展。轴突特别容易受到损伤和疾病的伤害,而轴突损伤则在神经退行性疾病中起到重要作用,因此,全面整合轴突导向信息将帮助我们了解细胞如何结合大量的细胞外信息以遵循正确的运输通道,以及促进损伤或疾病后轴突再生的线索是如何产生的。在中枢神经系统损伤和退变中,长期功能障碍的病因核心问题是缺乏有效的神经再生。在脊椎和无脊椎动物的中枢神经系统中,损伤后神经元的成长能力十分有限,这也表示了其在不良细胞环境中糟糕的再生能力。因此,深入了解调节轴突再生的分子途径可以为人类神经退行性疾病和中枢神经系统损伤的治疗带来有希望的靶标。中枢神经系统再生研究的一个主要目标是制定重新建立支配能力的策略。值得注意的是,许多参与神经再生的分子成员在胚胎发育过程中也会参与轴突生长和导向。强调参与轴突生长和导向的重要性能够与提高轴突再生的分子途径现有知识画等号。因此,利用生物模型(如果蝇)更多地了解轴突生长、导向及其再生是具有重要意义的。

Abstract:

Assembly, maintenance and repair of nervous systems rely on the precise coordination in the presentation of guidance signals and the correct reception and processing of these signals. During embryonic development, considerable progress has already been made in identifying the extracellular cues and the receptors mediating axonal guidance (Araújo and Tear, 2003). Axons are particularly vulnerable to injury and disease and axonal damage plays a central role in neurodegenerative disorders. Hence, full integration of axonal guidance information will help us understand how cells can combine extensive extracellular information to follow an unerring migration pathway. In addition, this understanding will yield clues on how to encourage axonal regeneration after injury or disease.