中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (12): 1949-1950.doi: 10.4103/1673-5374.172311

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

ROCK抑制:促视神经病变轴突再生新策略

  

  • 收稿日期:2015-11-13 出版日期:2015-12-30 发布日期:2015-12-30
  • 基金资助:

    Hercules基金;荷兰国家研究基金;Flemish科研基金

ROCK inhibition as a novel potential strategy for axonal regeneration in optic neuropathies

Inge Van Hove, Evy Lefevere, Lieve Moons *   

  1. Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (Van Hove I, Lefevere E, Moons L)
    Laboratory of Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium (Van Hove I)
  • Received:2015-11-13 Online:2015-12-30 Published:2015-12-30
  • Contact: Lieve Moons, Ph.D., Lieve.moons@bio.kuleuven.be.
  • Supported by:

    The authors are financially supported by the Hercules Grant [AKUL/09/038] and national Grants from the Research Council of KU Leuven [KU Leuven BOF-OT/10/033] and the Flemish Institute for the promotion of scientific research (IWT and FWO).

摘要:

青光眼或青光眼性视神经病变是世界范围导致失明的第二大原因。这种神经退行性病症以视网膜神经节细胞及轴突的缓慢和逐渐丧失为特征,并且经常与高眼压相关联。因此,目前青光眼的治疗重点在于减少眼高压。不幸的是,因青光眼与多因素疾病的病理生理相关,并非所有的患者受益于降眼压治疗。荷兰语天主教鲁汶大学生物学系Lieve Moons教授研究小组应用视神经断损伤小鼠作为青光眼病理学实验模型,力图确定新的神经保护/再生的分子,如Rho激酶抑制剂。Lieve Moons教授的目标是研究Rho激酶促进突起生长和实验性视神经病变模型轴突再生的结果。

Abstract:

ROCK signaling is clearly involved in a multitude of pathways, which are still mostly undiscovered in the injured/diseased CNS, thereby contributing to many pathological features, which prompts this kinase as a central target for the treatment of neurodegenerative disorders, such as glaucoma. It is increasingly recognized that strategies that aim to repair the functional connections following injury/lesions should attempt to target multiple pathways. ROCK inhibition or ROCK knockdown strategies clearly enables the stimulation of several repair processes and seems therefore, albeit in combination with other (growth)factors, a potential therapy for the treatment of this degenerative disease. Hence, it remains important to profoundly understand the pathological pathways and mechanisms underlying neurodegeneration and the restricted regeneration as it exists in the adult mammalian CNS. Interestingly, recent advances in the field have resulted in the identification and characterization of multiple novel candidate molecules/treatments able to support or induce processes related to neuroprotection and/or regeneration. Novel studies should consider these recent discoveries to create the best complementary combinatorial approach focusing on e.g., intrinsic growth stimulation with neutralization of glia/myelin-associated growth inhibitory factors, in order to obtain sufficient and proper regenerating axons in the brain target areas, thereby ultimately restoring functional connections. ROCK inhibition might as such be a versatile strategic partner in the search for novel treatment strategies for glaucoma, yet also for other neurodegenerative disorders.