中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (12): 1943-1944.doi: 10.4103/1673-5374.172312

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤后运动皮层兴奋性变化

  

  • 收稿日期:2015-11-11 出版日期:2015-12-30 发布日期:2015-12-30

Enhanced motor cortex excitability after spinal cord injury

Nardone Raffaele*   

  1. Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of
    Neurology, Franz Tappeiner Hospital, Merano, Italy; Spinal Cord Injury and Tissue Regeneration Center, Paracelsus Medical University, Salzburg, Austria
  • Received:2015-11-11 Online:2015-12-30 Published:2015-12-30
  • Contact: Raffaele Nardone, M.D., Ph.D.,raffaele.nardone@asbmeran-o.it.

摘要:

脊髓损伤后脊髓电路的重组发生在损伤处的上方和下方,这些功能性的变化可以通过电生理记录来检测。奥地利帕拉塞尔苏斯医科大学脊髓损伤及组织再生研究中心Dr. Raffaele Nardone研究发现,外伤性脊髓损伤患者电生理可检测出三叉神经 - 颈反射和三叉神经-脊髓反射,而在健康对照组人群中未检测到这些相关数据。此外,正常人群的颈部肌肉的肌电反应的振幅显著高于脊髓损伤的患者。

Abstract:

Transcranial magnetic stimulation (TMS) represents a useful non-invasive approach to studying cortical physiology, in addition to the descending motor pathways (Hallett, 2000), and may also be used to investigate the intracortical facilitatory and inhibitory mechanisms. TMS studies evaluating motor cortex excitability after incomplete spinal cord injury (SCI) have showed that the activity of intracortical inhibitory circuits may be reduced in these patients. We briefly illustrate and discuss here the most important TMS studies investigating cortical excitability in subjects with SCI.