中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (6): 937-943.doi: 10.4103/1673-5374.184492

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

人类大脑弓状束的发育

  

  • 收稿日期:2015-12-22 出版日期:2016-06-30 发布日期:2016-06-30
  • 基金资助:

    韩国教育科技部国家研究基金(2012-013997)

Developmental process of the arcuate fasciculus from infancy to adolescence: a diffusion tensor imaging study

Hyeong Jun Tak, Jin Hyun Kim, Su Min Son*   

  1. Department of Physical Medicine and Rehabilitation, School of Medicine, Yeungnam University, Daemyungdong, Namku, Daegu, Republic of Korea
  • Received:2015-12-22 Online:2016-06-30 Published:2016-06-30
  • Contact: Su Min Son, M.D., Ph.D., sumin430@hanmail.net.
  • Supported by:

    This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, No. 2012-013997.

摘要:

为研究人类典型发育过程中大脑弓状束的发育,我们应用弥散张量成像对96名0-14岁的发育期志愿者行弓状束前、后和直接神经纤维通路检测。对比分析3条主要神经纤维束成分--弓状束后、前、直接神经纤维束通路的检测成功率和各向异性值。除了弓状束后神经纤维束外,其他纤维束的检测成功率均随年龄的增长而升高(P< 0.05)。同侧大脑半球各神经纤维束的发育顺序依次为:弓状束后、前、直接神经纤维束通路。除了右侧弓状束直接神经纤维束通路外,其他弓状束神经纤维束的各向异性值均与年龄呈明显正相关(P< 0.05)。0-2岁女婴幼儿的弓状束神经纤维束检测成功率和各向异性值明显高于男婴幼儿。6-14岁儿童弓状束直接神经纤维束表现出更为明显的倾向于左侧大脑半球的不对称性。结果表明,人类婴儿至青少年期大脑弓状束各纤维成分发育存在明显的时序性,在发育早期存在性别差异,发育晚期存在大脑半球的不对称性。

orcid: 0000-0003-2818-3884 (Su Min Son)

关键词: 神经再生, 神经发育, 弓状束, 各向异性, 神经纤维束, 婴儿, 青少年

Abstract:

We investigated the radiologic developmental process of the arcuate fasciculus (AF) using subcomponent diffusion tensor imaging (DTI) analysis in typically developing volunteers. DTI data were acquired from 96 consecutive typically developing children, aged 0–14 years. AF subcomponents, including the posterior, anterior, and direct AF tracts were analyzed. Success rates of analysis (AR) and fractional anisotropy (FA) values of each subcomponent tract were measured and compared. AR of all subcomponent tracts, except the posterior, showed a significant increase with aging (P < 0.05). Subcomponent tracts had a specific developmental sequence: First, the posterior AF tract, second, the anterior AF tract, and last, the direct AF tract in identical hemispheres. FA values of all subcomponent tracts, except right direct AF tract, showed correlation with subject’s age (P < 0.05). Increased AR and FA values were observed in female subjects in young age (0–2 years) group compared with males (P < 0.05). The direct AF tract showed leftward hemispheric asymmetry and this tendency showed greater consolidation in older age (3–14 years) groups (P < 0.05). These findings demonstrated the radiologic developmental patterns of the AF from infancy to adolescence using subcomponent DTI analysis. The AF showed a specific developmental sequence, sex difference in younger age, and hemispheric asymmetry in older age.

Key words: nerve regeneration, development, arcuate fasciculus, fractional anisotropy, infants, adolescents, diffusion tensor imaging, neural regeneration