中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (11): 1790-1796.doi: 10.4103/1673-5374.194748

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

载脂蛋白E多态性与脑卒中后抑郁发病的关联性

  

  • 出版日期:2016-11-30 发布日期:2016-11-30
  • 基金资助:

    中国国家自然科学基金项目（81160146）

Apolipoprotein E polymorphisms increase the risk of post-stroke depression

Xue-bin Li1, 2, *, #, Jie Wang3, #, An-ding Xu1, *, Jian-min Huang2, Lan-qing Meng2, Rui-ya Huang2, Jun-li Wang4   

  1. 1 Stroke Center & Neurology Division, the First Afliated Hospital of Jinan University, Guangzhou, Guangdong Province, China 2 Department of Neurology, the Afliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China 3 Department of Nephrology, the Afliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China 4 Department of Laboratory Medicines, the Afliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China
  • Online:2016-11-30 Published:2016-11-30
  • Contact: Xue-bin Li, M.D. or An-ding Xu, Ph.D., yyfylxb@163.com or tlil@jnu.edu.cn.
  • Supported by:

    This study was supported in part by the National Natural Science Foundation of China, No. 81160146.

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摘要：

有研究显示，载脂蛋白E的基因多态性与神经退行性疾病发病有关，但目前尚不清楚其是否影响脑卒中后抑郁症。我们假设载脂蛋白E多态性有影响卒中后抑郁风险的可能，并通过对中国广西壮族自治区右江民族医学院附属医院的76例脑梗死伴有脑卒中后抑郁症的患者、88例脑梗死不伴有脑卒中后抑郁症的患者以及109例既无脑梗死又无脑卒中后抑郁症者进行比较，来分析载脂蛋白E rs429358与rs7412基因多态性与脑卒中后抑郁风险的可能关系。结果显示，3组研究对象的载脂蛋白E rs7412基因型分布情况接近；但载脂蛋白Ers429358 C等位基因增加了脑卒中后抑郁的风险。rs429358多态性影响脑卒中后抑郁患者的左颞叶相对局部脑血流量。此外，载脂蛋白E rs429358多态性不仅与抑郁症严重程度有关，而且与血清总胆固醇水平也有关。结果表明载脂蛋白E rs429358基因多态性与脑卒中后抑郁风险有关，并且载脂蛋白E rs429358等位基因C的基因型可能是脑卒中后神经恢复的有害因素，这一结果为未来干预脑卒中后抑郁发病提供了基因干预的临床数据。

orcid:0000-0003-3154-0985 (An-ding Xu)

关键词: 神经再生, 载脂蛋白E, 基因多态性, 脑卒中后抑郁, 风险, 区域静息态脑血流量, rs429358, rs7412, 脑梗死

Abstract:

Recent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression. Accordingly, we hypothesized that APOE polymorphisms modify the risk of post-stroke depression. Here, we performed a hospital-based case-control study (including 76 cerebral infarction cases with post-stroke depression, 88 cerebral infarction cases without post-stroke depression, and 109 controls without any evidence of post-stroke depression or cerebral infarction) to determine possible association between APOE rs429358 and rs7412 polymorphisms and risk of post-stroke depression. Our fndings show no difference among the groups with regards genotype distribution of the rs7412 polymorphism. In contrast, APOE genotypes with rs429358-C alleles increased the risk of post-stroke depression. Further, the rs429358 polymorphism was associated with significantly decreased regional cerebral blood flow values in the left temporal lobe of post-stroke depression cases. Additionally, the rs429358 polymorphism was not only associated with depression severity, but with increasing serum levels of total cholesterol. Tese results suggest that the APOE rs429358 polymorphism is associated with increased risk of developing post-stroke depression, and that APOE rs429358-C allele genotypes may be detrimental to recovery of nerve function afer stoke. Indeed, these fndings provide clinical data for future post-stroke depression gene interventions.

Key words: nerve regeneration, apolipoprotein E, genetic polymorphism, post-stroke depression, risk, regional resting-state cerebral blood ?ow, rs429358, rs7412, cerebral infarction, neural regeneration