中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (11): 1857-1864.doi: 10.4103/1673-5374.194759

• 综述:脑损伤修复保护与再生 • 上一篇    

大脑皮质扩散性抑制预处理

  

  • 出版日期:2016-11-30 发布日期:2016-11-30
  • 基金资助:
    中国国家自然科学基金项目(H0906-C090201);中国国家科技支撑项目(3G013F843428)

Cortical spreading depression-induced preconditioning in the brain

Ping-ping Shen, Shuai Hou, Di Ma, Ming-ming Zhao, Ming-qin Zhu, Jing-dian Zhang, Liang-shu Feng, Li Cui*, Jia-chun Feng*   

  1. Institute of Neuroscience Center and Neurology Department, the First Afliated Hospital of Jilin University, Changchun, Jilin Province, China
  • Online:2016-11-30 Published:2016-11-30
  • Contact: Li Cui, Ph.D. or Jia-chun Feng, Ph.D., chuili1967@126.com or fengjcfrank@qq.com.
  • Supported by:
    "This research was supported by the National Natural Science Foundation of China, No. H0906-C090201; a grant from the National Science and Technology Support Program of China, No. 3G013F843428."

摘要:

皮质扩散性抑制是产生神经元去极化的方法之一,在局灶性或全脑缺血过程中,皮质扩散性抑制预处理能增强后续损伤的耐受能力,但其机制尚待研究。为此,作者对皮质扩散性抑制预处理过程中,氯化钾的给药途径及浓度、诱导时间、保护时间窗、保护作用的区域及耐受细胞类型等进行分析,同时探讨了皮质扩散性抑制诱导的脑缺血耐受中兴奋性神经递质传递和代谢、一氧化氮、基因组重编程、炎症、神经营养因子与细胞应激反应等的作用机制,为皮质扩散性抑制预处理在神经保护与再生研究与临床应用方面提供理论依据。 

orcid: 0000-0002-5999-2492 (Jia-chun Feng)

关键词: 神经再生, 皮质扩散性抑制, 神经元去极化, 缺血耐受, 梗死周围去极化, 兴奋性神经递质, 一氧化氮, 基因组重编程, 炎症, 神经营养因子, 细胞应激反应

Abstract: Cortical spreading depression is a technique used to depolarize neurons. During focal or global ischemia, cortical spreading depression-induced preconditioning can enhance tolerance of further injury. However, the underlying mechanism for this phenomenon remains relatively unclear. To date, numerous issues exist regarding the experimental model used to precondition the brain with cortical spreading depression, such as the administration route, concentration of potassium chloride, induction time, duration of the protection provided by the treatment, the regional distribution of the protective effect, and the types of neurons responsible for the greater tolerance. In this review, we focus on the mechanisms underlying cortical spreading depression-induced tolerance in the brain, considering excitatory neurotransmission and metabolism, nitric oxide, genomic reprogramming, in?ammation, neurotropic factors, and cellular stress response. Specifcally, we clarify the procedures and detailed information regarding cortical spreading depression-induced preconditioning and build a foundation for more comprehensive investigations in the feld of neural regeneration and clinical application in the future.

Key words: nerve regeneration, cortical spreading depression, neuronal depolarization, ischemic tolerance, peri-infarct depolarization, excitatory neurotransmission, nitric oxide, genomic reprogramming, in?ammation, neurotropic factors, cellular stress response, neural regeneration