中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (8): 1711-1716.doi: 10.4103/1673-5374.332130

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

髓过氧化物酶:治疗脑卒中的新靶点?

  

  • 出版日期:2022-08-15 发布日期:2022-01-21
  • 基金资助:
    国家自然科学基金项目(81771297);兰州大学第二医院“萃英科技创新”计划项目(CY2017-MS04);秦惠君与李政道中国大学生见习进修基金(LZU-JZH2224);国家大学生创新创业人才培养计划项目(201910730212);兰州大学第二医院本科生萃英科学培训计划项目(CYXZ2019-06)

Myeloperoxidase: a new target for the treatment of stroke?

Yun-Chang Wang1, 2, 3, #, Yu-Bao Lu1, 2, 4, #, Xiao-Lan Huang5, Yong-Feng Lao1, Lu Zhang1, Jun Yang1, Mei Shi1, Hai-Long Ma1, Ya-Wen Pan1, 2, *, Yi-Nian Zhang1, 2, *   

  1. 1The Second Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, China; 2Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China; 3Xiangya Hospital, Central South University, Changsha, Hunan Province, China; 4Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China; 5University of Chinese Academy of Sciences, Beijing, China
  • Online:2022-08-15 Published:2022-01-21
  • Contact: Yi-Nian Zhang, MD, PhD, ery_zhangyinian@lzu.edu.cn; Ya-Wen Pan, MD, PhD, panyawen666@sohu.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81771297 (to YNZ); CuiYing Scientific and Technological Innovation Program of Lanzhou University Second Hospital of China, No. CY2017-MS04 (to YNZ); Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Research Endowment of China, No. LZU-JZH2224 (to YCW); National Innovation and Entrepreneurship Training Program for Undergraduate of China, No. 201910730212 (to YCW); and CuiYing Scientific Training Program for Undergraduates of Lanzhou University Second Hospital of China, No. CYXZ2019-06 (to YCW).

摘要:

髓过氧化物酶是髓样系统中的重要炎症因子,主要分布在嗜中性粒细胞和小胶质细胞中。髓过氧化物酶及其活性产物可参与出血性脑卒中和缺血性脑卒中的发生和发展,如对血脑屏障和大脑损害等。作为一种特殊的炎症标记物,髓过氧化物酶的价值不仅体现在脑卒中血管疾病的发生和发展评估中,更重要的是有大量的基础实验和临床研究表明,抑制或缺乏髓过氧化物酶可影响脑卒中的预后。文章总结了髓过氧化物酶在脑卒中后发展为血管损伤和继发性脑损伤过程中的潜在作用,并探索了抑制髓过氧化物酶对脑卒中预后的作用,还分析了髓过氧化物酶在脑卒中发生和发展中的意义,并讨论其是否可作为治疗和预测脑卒中的靶点。

https://orcid.org/0000-0003-3518-7154 (Yun-Chang Wang); https://orcid.org/0000-0003-4375-8316 (Yu-Bao Lu)

关键词: 脑卒中, 髓过氧化物酶, 炎症, 血脑屏障, 出血性脑卒中, 缺血性脑卒中, 继发性脑损伤, 中性粒细胞, 小胶质细胞

Abstract: Myeloperoxidase is an important inflammatory factor in the myeloid system, primarily expressed in neutrophils and microglia. Myeloperoxidase and its active products participate in the occurrence and development of hemorrhagic and ischemic stroke, including damage to the blood-brain barrier and brain. As a specific inflammatory marker, myeloperoxidase can be used in the evaluation of vascular disease occurrence and development in stroke, and a large amount of experimental and clinical data has indicated that the inhibition or lack of myeloperoxidase has positive impacts on stroke prognosis. Many studies have also shown that there is a correlation between the overexpression of myeloperoxidase and the risk of stroke. The occurrence of stroke not only refers to the first occurrence but also includes recurrence. Therefore, myeloperoxidase is significant for the clinical evaluation and prognosis of stroke. This paper reviews the potential role played by myeloperoxidase in the development of vascular injury and secondary brain injury after stroke and explores the effects of inhibiting myeloperoxidase on stroke prognosis. This paper also analyzes the significance of myeloperoxidase etiology in the occurrence and development of stroke and discusses whether myeloperoxidase can be used as a target for the treatment and prediction of stroke.

Key words: blood-brain barrier, hemorrhagic stroke, inflammation, ischemic stroke, microglia, myeloperoxidase, neutrophils, secondary brain injury, stroke