中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (1): 43-46.doi: 10.4103/1673-5374.198972

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

再生医学结合康复方法治疗慢性脊髓损伤的前景

  

  • 收稿日期:2017-01-14 出版日期:2017-01-15 发布日期:2017-01-15
  • 基金资助:

     

    此项研究得到日本科学技术-加利福尼亚再生医学研究所合作计划，日本科学促进协会科学研究资助计划，日本文部科学省的基金支持。此项研究还得到日本科技部再生医学实现研究中心网的基金支持和日本医学研究与发展部对HO和MN的基金支持以及日本通用保险协会的基金支持。HO是SanBio有限公司有偿科学顾问委员，并且他获得Keio Gijuku学术奖，作为来自日本文部科学省在创新领域科学研究（综合脑科学网）的财政补贴。

The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models

Syoichi Tashiro1, Masaya Nakamura2, Hideyuki Okano3, *   

  1. 1. Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan; 
    2. Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan; 3. Department of Physiology, Keio University School of Medicine, Tokyo, Japan
  • Received:2017-01-14 Online:2017-01-15 Published:2017-01-15
  • Contact: Hideyuki Okano, M.D., Ph.D., hidokano@a2.keio.jp.
  • Supported by:

    The authors disclose the following financial support for the research, authorship, and/or publication of this article. This work was supported by grants from the following organisations: the Japan Science and Technology-California Institute for Regenerative Medicine collaborative program; the Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (SPS); and the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT). This work was also supported by the Research Centre Network for Realization of Regenerative Medicine of the Japan Science and Technology Agency (JST) and the Japan Agency for Medical Research and Development(AMED; to HO and MN) and by the General Insurance Association of Japan.

PDF

485

摘要：

在多种疾病和损伤动物模型的神经再生研究中，干细胞医学的快速发展正在得以实现。关于脊髓损伤，研究人员已经报道了一些显著的后遗症恢复范例，例如，运动不全麻痹和痉挛，感觉功能障碍以及泌尿功能障碍，这些成功案例采用了多种细胞来源，如神经干/祖细胞和间充质干细胞，尤其是在从严重到亚严重期的实验动物身上效果显著。通过对比，虽然慢性脊髓损伤患者与严重到亚严重期患者数量相比要高出50多倍，但是仅有少量研究专注于对慢性脊髓损伤的治疗，因此在治疗中细胞再生医学看起来没什么作用。在文中，我们总结了近期关于结合神经干/祖细胞移植和踏车训练方法的研究，并讨论了再生医学与其他治疗方法结合的前景。

ORCID: 0000-0001-7482-5935(Hideyuki Okano)

Abstract:

Regenerative medicine has opened a window for functional recovery in acute-to-subacute phase spinal cord injury (SCI). By contrast, there are still only a few studies have focused on the treatment of the chronically injured spinal cord, in which cell-based regenerative medicine seems less effective. Since the majority of SCI patients are in the chronic phase, representing a major challenge for the clinical application of cell-based regenerative medicine. Although combined therapies for the treatment of chronic SCI have attracted attention of researchers and its potential importance is also widely recognized, there had been very few studies involving rehabilitative treatments to date. In a recent study, we have demonstrated for the first time that treadmill training combined with cell transplantation significantly promotes functional recovery even in chronic SCI, not only in additive but also in synergistic manner. Even though we have succeeded to outline
the profiles of recovery secondary to the combination therapy, the mechanism underlying the effects remain unsolved. In this review article, we summarize the present progress and consider the prospect of the cell-based regenerative medicine particularly combined with rehabilitative approaches for chronic SCI animal models.

Key words: transplantation, spinal cord injury, regenerative medicine, chronic phase, rehabilitation, treadmill training