中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (5): 787-794.doi: 10.4103/1673-5374.206650

• 原著:退行性病与再生 • 上一篇    下一篇

多发性硬化患者大脑白质损伤与灰质病变的关系

  

  • 收稿日期:2017-04-24 出版日期:2017-05-15 发布日期:2017-05-15
  • 基金资助:

    吉林省科技厅项目（20160101023JC）

Correlation between white matter damage and gray matter lesions in multiple sclerosis patient

Xue-mei Han1, Hong-ji Tian1, Zheng Han1, Ce Zhang2, Ying Liu1, Jie-bing Gu1, Rohit Bakshi3, Xia Cao4   

  1. 1 First Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China; 2 Department of Clinical Medicine (Grade 2013 Student), School of Clinical Medicine, Jilin University, Changchun, Jilin Province, China; 3 Department of Neurology, Brigham and Women’s Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA, USA; 4 School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin Province, China
  • Received:2017-04-24 Online:2017-05-15 Published:2017-05-15
  • Contact: Xia Cao, Ph.D.,caoxia@jlu.edu.cn.
  • Supported by:

    This study was financially supported by the Project of Science and Technology Department of Jilin Province in China, No. 20160101023JC.

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摘要：

基于体素的形态测量学可用于评价脑结构变化，基于纤维束示踪的空间统计方法可能量化分析脑白质的变化程度。为此，实验对比了20例复发缓解型多发性硬化患者及20名健康志愿者的头部弥散张量成像结果，发现患者大脑白质纤维束、胼胝体膝部及压部、左侧丘脑前辐射、左侧海马、左侧钩束、右侧皮质脊髓束、双侧扣带回及双侧下纵束各向异性下降，大脑灰质体积减小，且其中右额叶（额上回、额中回、中央前回、眶回）、右顶叶（中央后回和顶下小叶）、右侧颞叶（尾状核）、右枕叶（枕中回）、右侧岛叶、右侧海马旁回和左侧扣带回的灰质体积变化明显，灰质萎缩体积与白质相关纤维各向异性呈正相关。结果说明多发性硬化患者大脑白质纤维束存在大规模损伤，灰质萎缩主要发生在额叶、顶叶、尾状核、海马旁回、扣带回，且灰质萎缩与白质损伤密切相关，尤其与关联纤维损伤有关。

ORCID：0000-0002-3008-4685(Xia Cao)

关键词: 神经再生, 多发性硬化, 弥散张量成像, 基于纤维束示踪的空间统计方法, 基于体素的形态测量学, 灰质, 白质, 各向异性, 脑萎缩

Abstract:

We observed the characteristics of white matter fibers and gray matter in multiple sclerosis patients, to identify changes in diffusion tensor imaging fractional anisotropy values following white matter fiber injury. We analyzed the correlation between fractional anisotropy values and changes in whole-brain gray matter volume. The participants included 20 patients with relapsing-remitting multiple sclerosis and 20 healthy volunteers as controls. All subjects underwent head magnetic resonance imaging and diffusion tensor imaging. Our results revealed that fractional anisotropy values decreased and gray matter volumes were reduced in the genu and splenium of corpus callosum, left anterior thalamic radiation, hippocampus, uncinate fasciculus, right corticospinal tract, bilateral cingulate gyri, and inferior longitudinal fasciculus in multiple sclerosis patients. Gray matter volumes were significantly different between the two groups in the right frontal lobe (superior frontal, middle frontal, precentral, and orbital gyri), right parietal lobe (postcentral and inferior parietal gyri), right temporal lobe (caudate nucleus), right occipital lobe (middle occipital gyrus), right insula, right parahippocampal gyrus, and left cingulate gyrus. The voxel sizes of atrophic gray matter positively correlated with fractional anisotropy values in white matter association fibers in the patient group. These findings suggest that white matter fiber bundles are extensively injured in multiple sclerosis patients. The main areas of gray matter atrophy in multiple sclerosis are the frontal lobe, parietal lobe, caudate nucleus, parahippocampal gyrus, and cingulate gyrus. Gray matter atrophy is strongly associated with white matter injury in multiple sclerosis patients, particularly with injury to association fibers.

Key words: nerve regeneration, multiple sclerosis, diffusion tensor imaging, tract-based spatial statistics, voxel-based morphometry, gray matter, white matter, fractional anisotropy, brain atrophy, neural regeneration