中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (8): 1352-1356.doi: 10.4103/1673-5374.213558

• 原著:退行性病与再生 • 上一篇    下一篇

视光学相干层析成像与T细胞基因表达分析:可早期诊断良性多发性硬化?

  

  • 收稿日期:2017-07-22 出版日期:2017-08-15 发布日期:2017-08-15

Optical coherence tomography and T cell gene expression analysis in patients with benign multiple sclerosis

John Soltys1, Qin Wang2, Yang Mao-Draayer2   

  1. 1 Present Address: University of Colorado Medical Scientist Training Program (MSTP), Aurora, CO, USA;             
    2 Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA
  • Received:2017-07-22 Online:2017-08-15 Published:2017-08-15
  • Contact: Yang Mao-Draayer, M.D.,Ph.D., maodraay@umich.edu.
  • Supported by:

    This study was funded by an investigator-initiated, unrestricted research grant (to YMD) from Biogen Idec. YMD served as a consultant and/or received grant support from: Acorda, Bayer Pharmaceutical, EMD Serono, Genzyme, Novartis, Questor, Teva Neuroscience and Chugai Pharma. Dr. YMD is currently supported by grants from NIH NIAID Autoimmune Center of Excellence: UM1-AI110557; NIH NINDS R01-NS080821, Novartis and Chugai (to YMD).

摘要:

良性多发性硬化的确诊一般是基于非运动症状进展下的回顾性诊断。最近的研究显示,需要更多的前瞻性方法早期诊断非运动症状的良性多发性硬化,以便直接指导针对此病的干预和治疗。此次小样本良性多发性硬化病例系列研究展现了视光学相干层析成像与T细胞基因表达分析结果。结果显示,良性多发性硬化患者视网膜神经纤维层厚度轻度变薄,且T细胞中白细胞介素10和白血病抑制因子mRNA表达明显上调,而白细胞介素6和高亲和力神经降压素受体1mRNA表达明显下调。试验结果为应用视光学相干层析成像和T细胞基因表达分析作为前瞻性诊断良性多发性硬化的方法奠定了基础。

orcid:0000-0001-6248-3480(Yang Mao-Draayer)

关键词: 神经再生, 良性多发性硬化, 视光学相干层析成像, T细胞, 白细胞介素10, 白血病抑制因子, 视神经炎

Abstract:

Benign multiple sclerosis is a retrospective diagnosis based primarily on a lack of motor symptom progression. Recent findings that suggest patients with benign multiple sclerosis experience non-motor symptoms highlight the need for a more prospective means to diagnose benign multiple sclerosis early in order to help direct patient care. In this study, we present optical coherence tomography and T cell neurotrophin gene analysis findings in a small number of patients with benign multiple sclerosis. Our results demonstrated that retinal nerve fiber layer was mildly thinned, and T cells had a distinct gene expression profile that included upregulation of interleukin 10 and leukemia inhibitory factor, downregulation of interleukin 6 and neurotensin high affinity receptor 1 (a novel neurotrophin receptor). These findings add evidence for further investigation into optical coherence tomography and mRNA profiling in larger cohorts as a potential means to diagnose benign multiple sclerosis in a more prospective manner.

Key words: neurotensin high affinity receptor 1, benign multiple sclerosis, optical coherence tomography, interleukin 10, T cell, leukemia inhibitory factor, optic neuritis, neural regeneration