中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (4): 727-730.doi: 10.4103/1673-5374.230304

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

人脑前庭神经核的结构性神经连接：来自弥散张量纤维束成像的证据

  

  • 收稿日期:2017-05-10 出版日期:2018-04-15 发布日期:2018-04-15
  • 基金资助:

    韩国教育部国家研究基金

"Structural neural connectivity of the vestibular nuclei in the human brain: a diffusion tensor imaging study

Sung Ho Jang1, Mi Young Lee2, Sang Seok Yeo3, Hyeok Gyu Kwon4   

  1. 1 Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namku, Daegu, Republic of Korea
    2 Department of Physical Therapy, College of Health and Therapy, Daegu Haany University, Gyeongsan, North Gyeongsang, Republic of Korea
    3 Department of Physical Therapy, College of Health Sciences, Dankook University, Dandaero, Cheonan, Republic of Korea
    4 Department of Physical Therapy, College of Health Sciences, Catholic University of Pusan, Pusan, Republic of Korea
  • Received:2017-05-10 Online:2018-04-15 Published:2018-04-15
  • Contact: Hyeok Gyu Kwon, Ph.D.,khg0715@hanmail.net
  • Supported by:

    This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A4A01020385).

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摘要：

既往有很多关于前庭神经核神经连接的动物研究，但在人脑中的此类研究尚十分有限。此研究纳入了37名健康受试者，应用弥散张量纤维束成像对其前庭神经核与其他几乎所有脑区的神经连接进行了研究。发现前庭神经核与小脑、丘脑、动眼神经核（ON），滑车神经核（TN），展神经核（AN）和网状结构（RF）100％的连接。前庭神经核显示出分别与初级运动皮质、初级躯体感觉皮质、运动前区皮质、下丘脑、后顶叶皮质、外侧前额叶皮质、腹正中前额皮质、眶额叶皮质有95.9％，90.5％，87.8％，86.5％，75.7％， 70.3％，51.4％和40.5％的连接。前庭神经核显示出与其功能相关的脑区小脑、丘脑、动眼神经核、滑车神经核、展神经核和网状结构的高度神经连接性，从而参与控制平衡、眼动、运动意识和空间定位。

orcid:0000-0002-6654-302X(Hyeok Gyu Kwon)

 

关键词: 神经再生, 前庭神经核, 神经连接, 弥散张量纤维束成像, 小脑, 动眼神经核

Abstract:

Many animal studies have reported on the neural connectivity of the vestibular nuclei (VN). However, little is reported on the structural neural connectivity of the VN in the human brain. In this study, we attempted to investigate the structural neural connectivity of the VN in 37 healthy subjects using diffusion tensor tractography. A seed region of interest was placed on the isolated VN using probabilistic diffusion tensor tractography. Connectivity was defined as the incidence of connection between the VN and each brain region. The VN showed 100% connectivity with the cerebellum, thalamus, oculomotor nucleus, trochlear nucleus, abducens nucleus, and reticular formation, irrespective of thresholds. At the threshold of 5 streamlines, the VN showed connectivity with the primary motor cortex (95.9%), primary somatosensory cortex (90.5%), premotor cortex (87.8%), hypothalamus (86.5%), posterior parietal cortex (75.7%), lateral prefrontal cortex (70.3%), ventromedial prefrontal cortex (51.4%), and orbitofrontal cortex (40.5%), respectively. These results suggest that the VN showed high connectivity with the cerebellum, thalamus, oculomotor nucleus, trochlear nucleus, abducens nucleus, and reticular formation, which are the brain regions related to the functions of the VN, including equilibrium, control of eye movements, conscious perception of movement, and spatial orientation.

Key words: nerve regeneration, vestibular nuclei, neural connectivity, diffusion tensor tractography, cerebellum, oculomotor nucleus, neural regeneration