中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (10): 1851-1856.doi: 10.4103/1673-5374.238716

• 原著:视神经损伤修复保护与再生 • 上一篇    

眼运动神经麻痹量表的有效性和可靠性

  

  • 收稿日期:2018-06-25 出版日期:2018-10-15 发布日期:2018-10-15

Validity and reliability of the Ocular Motor Nerve Palsy Scale

Ling-Yun Zhou, Chang Su, Tie-Juan Liu, Xue-Mei Li   

  1. Ocular Motility Disorder Treatment & Rehabilitation Center, Department of Acupuncture, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
  • Received:2018-06-25 Online:2018-10-15 Published:2018-10-15
  • Contact: Ling-Yun Zhou, PhD, MD,no1zhly@163.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81674052.

PDF

215

摘要：

客观准确的评价眼运动神经麻痹疾病程度不仅有助于预后评估，更是筛选治疗方法的基础，但目前对其严重程度的评估并没有一个全面的衡量方法。文章介绍了课题组自主研发的用于衡量眼运动神经麻痹病情程度的量表，并评价其效度和信度。将该量表交与6名相关专家通过电子邮件的形式进行打分，评价其内容效度。我们招募了106例确诊为单侧孤立性眼运动神经麻痹患者，3名医生分别用本量表对患者进行评分，其中1名医生间隔24 h后进行1次重复测量得出数据。应用内容效度指数和因子分析评价本量表的效度，应用ICC系数和克朗巴赫系数对量表的组间和组内信度及内部一致性进行分析。结果显示，内容效度指数检测结果(I-CVI=1.0，S-CVI=0.9，Pc=0.016，K* =1)证明本量表具有良好的内容效度。因子分析中抽取出2个公因子累积贡献率达85.2%，而且各因子上项目的因子载荷都超过0.8，量表具有良好的结构效度。组内信度ICC系数为0.965(P ＜0.01)，重测信度的ICC系数为0.976(P＜0.01)，克朗巴赫系数为0.63-0.70，说明量表具有良好的信度。上述数据可证实，眼运动神经麻痹评分量表具有良好的信度和效度，可以应用于评价眼运动神经麻痹的严重程度，稳定可靠。研究的临床试验方案注册于中国临床试验注册中心，注册号为：ChiCTR-OOC-17010702。

orcid:0000-0001-6659-3839(Ling-Yun Zhou)

关键词: 动眼神经麻痹量表, 动眼神经麻痹, 外展神经麻痹, 滑车神经麻痹, 效度, 信度, 内部一致性, 复视, 眼球运动障碍, 上睑下垂, 神经再生

Abstract:

Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehensive measure of its severity. In this study, we designed the Ocular Motor Nerve Palsy Scale and investigated its validity and reliability. Six experts were invited to grade and evaluate the scale. The study recruited 106 patients with a definite diagnosis of unilateral isolated ocular motor nerve palsy. Three physicians evaluated the patients using the scale. One of the three physicians evaluated the patients again after 24 hours. The content validity index (CVI) and factor analysis were used to analyze the scale’s construct validity. The intraclass correlation coefficient and Cronbach’s alpha were used to evaluate the inter-rater and test-retest reliability and the internal consistency. The CVI results (I-CVI = 1.0, S-CVI = 0.9, Pc = 0.016, K* = 1) indicated good content validity. Factor analysis extracted two common factors that accounted for 85.2% of the variance. Furthermore, the load value of each component was above 0.8, indicating good construct validity. The Ocular Motor Nerve Palsy Scale was found to be highly reliable, with an inter-rater reliability intraclass correlation coefficient of 0.965 (P < 0.01), a test-retest reliability intraclass correlation coefficient of 0.976 (P < 0.01), and Cronbach’s alpha values of 0.63–0.70. In conclusion, the Ocular Motor Nerve Palsy Scale with good validity and reliability can be used to quantify the severity of ocular motor nerve palsy. This study was registered at Chinese Clinical Trial Registry (registration number: ChiCTR-OOC-17010702).

Key words: nerve regeneration, Ocular Motor Nerve Palsy Scale, oculomotor nerve paralysis, abducens nerve paralysis, trochlear nerve paralysis, validity, reliability, internal consistency, diplopia, eyeball movement disorder, ptosis, neural regeneration