中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (6): 991-996.doi: 10.4103/1673-5374.250578

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

以精确运动评价创伤性脑损伤大动物的神经功能

  

  • 出版日期:2019-06-15 发布日期:2019-06-15
  • 基金资助:

    中国国家自然科学基金项目(11672332,11102235,31200809),国家重点研发计划(2016YFC1101500),天津市科技项目(17YFZCSY00620,16ZXHLSY00120)

Neurological functional evaluation based on accurate motions in big animals with traumatic brain injury

Ji-Peng Jiang 1 , Xue-Gang Niu 2 , Chen Dai 1 , Ke Ma 1 , Hui-You Xu 1 , Shi-Xiang Cheng 1 , Zhi-Wen Zhang 3 , Feng Duan 3 , Xu Zhu 4 , Yu-Ting Wang 4 , Xu-Yi Chen 1 , Sai Zhang 1   

  1. 1 Center for Neurology and Neurosurgery, Medical Center of People’s Armed Policed Force, Key Laboratory of Neurotrauma Repair of Tianjin, Tianjin, China
    2 Department of Neurosurgery, Tianjin Fourth Central Hospital, Tianjin, China
    3 Department of Automation, College of Computer and Control Engineering, Nankai University, Tianjin, China
    4 Graduate School, Tianjin Medical University, Tianjin, China
  • Online:2019-06-15 Published:2019-06-15
  • Contact: Xu-Yi Chen, MD, chenxuyi1979@126.com; Sai Zhang, MD, Zhangsai718@yahoo.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 11672332, 11102235 and 31200809 (all to XYC); the National Key Research and Development Plan of China, No. 2016YFC1101500 (to SZ); and the Science and Technology Program of Tianjin, China, No. 17YFZCSY00620 and 16ZXHLSY00120 (both to XYC).

摘要:

准确有效的神经学评估方法对于创伤性脑损伤的治疗和康复是十分必要的,但是目前尚不能客观、直观的评价大动物的神经功能,且难以量化损坏和恢复的程度。实验通过冲击比格犬大脑皮质运动区建立创伤性脑损伤大动物模型,2个月后以三维运动捕捉、肌电图和地面反作用力评估其运动功能,通过比格犬关节轨迹、关节距离变化、关节角度变化、终点高度变化、肌电图信号以及垂直地面反作用力变化,可以直观地检测出创伤性脑损伤比格犬的神经功能缺陷。

orcid: 0000-0002-8954-7277 (Ji-Peng Jiang)

关键词: 神经功能评价方法, 神经缺陷, 创伤性脑损伤, 动作捕捉, 肌电图, 地面反作用力, 比格犬, 神经再生

Abstract:

An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury. However, most of the existing evaluation methods in basic research and clinical practice are not objective or intuitive for assessing the neurological function of big animals, and are also difficult to use to qualify the extent of damage and recovery. In the present study, we established a big animal model of traumatic brain injury by impacting the cortical motor region of beagles. At 2 weeks after successful modeling, we detected neurological deficiencies in the animal model using a series of techniques, including three-dimensional motion capture, elec¬tromyogram and ground reaction force. These novel technologies may play an increasingly important role in the field of traumatic brain injury diagnosis and rehabilitation in the future.

Key words: nerve regeneration evaluation method, neurological deficiency, traumatic brain injury, motion capture, electromyogram, ground reaction force, neural regeneration