中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (9): 1631-1638.doi: 10.4103/1673-5374.276324

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

干细胞旁分泌特性可作为视网膜神经退行性疾病的潜在神经保护疗法

  

  • 出版日期:2020-09-08 发布日期:2020-09-24

Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases

Kevin Puertas-Neyra1, #, Ricardo Usategui-Martín1, #, Rosa M. Coco1, 2, 3, Ivan Fernandez-Bueno1, 2, 3, *   

  1. 1 Instituto Universitario de Oftalmobiología Aplicada, Universidad de Valladolid, Valladolid, Spain 2 Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León, Valladolid, Spain 3 Red Temática de Investigación Cooperativa en Salud, Oftared, Instituto de Salud Carlos III, Valladolid, Spain
  • Online:2020-09-08 Published:2020-09-24
  • Contact: Ivan Fernandez-Bueno, PhD, ifernandezb@ioba.med.uva.es.
  • Supported by:
    KPN, RUM, and IFB were supported by Fundación Carolina, Madrid, Spain; Fondo Europeo de Desarrollo Regional, Fondo Social Europeo, and Consejería de Educación (Grant VA077P17), Junta de Castilla y León, Spain; and Centro en Red de Medicina Regenerativa y Terapia Celular, Junta de Castilla y León, Spain, respectively.

摘要: orcid: 0000-0003-3380-4040 (Ivan Fernandez-Bueno)

Abstract: Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many pathologies included under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients’ daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being investigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially protect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strategies will address the unmet therapeutic needs.

Key words: clinical trials, growth factors, intraocular injection, intravitreal injection, neuroprotection, paracrine properties, photoreceptors, preclinical models, retinal diseases, stem cells