中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (8): 1558-1559.doi: 10.4103/1673-5374.303015

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

无创电刺激作为视网膜退行性疾病的潜在治疗方法

  

  • 出版日期:2021-08-15 发布日期:2021-01-13

Non-invasive electrical stimulation as a potential treatment for retinal degenerative diseases

Karen Chang, Sam Enayati, Kin-Sang Cho, Tor P. Utheim*, Dong Feng Chen*   

  1. Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA (Chang K, Enayati S, Cho KS, Utheim TP, Chen DF)
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway (Chang K, Enayati S, Utheim TP)
    Department of Ophthalmology, Drammen Hospital, Norway (Enayati S, Utheim TP)
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Tor Paaske Utheim, MD, PhD, t.p.utheim@odont.uio.no; Dong Feng Chen, MD, PhD, Dongfeng_Chen@MEEI.HARVARD.EDU.
  • Supported by:
    The present perspective paper was supported by grants from the National Institutes of Health/National Eye Institute (EY025913, EY025259, to DFC), Massachusetts Lions Foundation (to DFC and KSC), the Norwegian Research Council 276100 (to TPU), the South-Eastern Norway Regional Health Authority (to TPU), and Norwegian Association of the Blind and Partially Sighted (to TPU), Ministry of Science and Technology MOST 109-2917-I-564 -032 (to PPU), BrightFocus Foundation (to KSC). 

摘要: https://orcid.org/0000-0002-3821-6777 
(Tor Paaske Utheim)
https://orcid.org/0000-0001-6283-8843
(Dong Feng Chen)

Abstract: More than 38.5 million people are estimated to be affected by blindness worldwide in 2020 (Flaxman et al., 2017). Among the diseases that cause visual impairment, refractive errors are typically corrected with glasses and cataract with surgery. The leading causes of irreversible blindness nowadays are usually degenerative diseases related to the retina and its extending optic nerves, such as glaucoma, age-related macular degeneration, and retinitis pigmentosa (Quigley et al., 2006; Flaxman et al., 2017). The regenerative ability of the adult central nervous system in mammals is limited. As part of the central nervous system, impairments of the retina and optic nerve caused by trauma or diseases often lead to neurodegeneration and result in permanent blindness, which currently remains no cures. As the global population grows and ages, the number of people with vision loss will also increase. However, treatments for retinal degenerative diseases remain as unmet medical needs.