中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (11): 2250-2256.doi: 10.4103/1673-5374.310692

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

大鼠纹状体尾壳核在耳鸣中的感觉门控的作用

  

  • 出版日期:2021-11-15 发布日期:2021-04-13
  • 基金资助:

    中国国家自然科学基金项目（21790391，81870727）

Role of the caudate-putamen nucleus in sensory gating in induced tinnitus in rats

Meng-Lin Wang, Yu Song, Jun-Xiu Liu, Ya-Li Du, Shan Xiong, Xin Fan, Jiang Wang, Zhi-Di Zhang, Lan-Qun Mao, Fu-Rong Ma#br#   

  1. 1Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, China; 2Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, the Chinese Academy of Sciences, Beijing, China
  • Online:2021-11-15 Published:2021-04-13
  • Contact: Fu-Rong Ma, MD, PhD, furongma@126.com; Lan-Qun Mao, PhD, lqmao@iccas.ac.cn.
  • Supported by:
    This study was supported by the National Natural Science Foundation of China, Nos. 21790391 (to LQM) and 81870727 (to FRM).

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摘要：

耳鸣是一种没有对外界刺激产生有意识的声音感知，伴有焦虑、抑郁和失眠等。耳鸣的临床治疗往往不能取得满意的疗效，其潜在机制仍不清楚。最近的研究表明尾壳核可能作为感觉门控核团，参与耳鸣的噪声消除机制，但其潜在作用还有待进一步验证。为探究尾壳核在水杨酸钠诱导大鼠耳鸣模型中的潜在作用，通过腹腔注射350 mg/kg水杨酸钠诱导耳鸣大鼠模型，可见大鼠纹状体尾壳核神经元自发放电率明显增加，而多巴胺水平下降。电刺激纹状体尾壳核后，初级听觉皮质神经元自发放电频率明显恢复。结果表明纹状体尾壳核在水杨酸钠诱导的耳鸣中起到感觉门控作用。研究于2017年12月6日经经北京大学医学部动物伦理委员会批准，批准号A2010031。

https://orcid.org/0000-0002-5068-9980 (Fu-Rong Ma); https://orcid.org/0000-0001-8286-9321 (Lan-Qun Mao); 
https://orcid.org/0000-0002-3689-1584 (Meng-Lin Wang); https://orcid.org/0000-0002-5216-8740 (Yu Song); 
https://orcid.org/0000-0002-5205-5244 (Ya-Li Du); https://orcid.org/0000-0003-2833-913X (Shan Xiong); 
https://orcid.org/0000-0001-9705-0650 (Xin Fan); https://orcid.org/0000-0001-6597-5501 (Jiang Wang)

关键词:

耳鸣, 纹状体, 尾壳核, 初级听觉皮质, 脑深部刺激, 水杨酸钠, 多巴胺, 声音

Abstract: Tinnitus can be described as the conscious perception of sound without external stimulation, and it is often accompanied by anxiety, depression, and insomnia. Current clinical treatments for tinnitus are ineffective. Although recent studies have indicated that the caudate-putamen nucleus may be a sensory gating area involved in noise elimination in tinnitus, the underlying mechanisms of this disorder are yet to be determined. To investigate the potential role of the caudate-putamen nucleus in experimentally induced tinnitus, we created a rat model of tinnitus induced by intraperitoneal administration of 350 mg/kg sodium salicylate. Our results revealed that the mean spontaneous firing rate of the caudate-putamen nucleus was increased by sodium salicylate treatment, while dopamine levels were decreased. In addition, electrical stimulation of the caudate-putamen nucleus markedly reduced the spontaneous firing rate of neurons in the primary auditory cortex. These findings suggest that the caudate-putamen nucleus plays a sensory gating role in sodium salicylate-induced tinnitus. This study was approved by the Institutional Animal Care and Use Committee of Peking University Health Science Center (approval No. A2010031) on December 6, 2017.

Key words: caudate-putamen nucleus, deep brain stimulation, dopamine, primary auditory cortex, sodium salicylate, sound
striatum, tinnitus

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