中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (2): 311-314.doi: 10.4103/1673-5374.265559

• 原著:视神经损伤修复保护与再生 • 上一篇    下一篇

多巴胺水平影响孔源性视网膜脱离患者的视力？

  

  • 出版日期:2020-02-15 发布日期:2020-05-25

Is there a relationship between dopamine and rhegmatogenous retinal detachment?

Alessio Martucci1 , Massimo Cesareo1, Maria Dolores Pinazo-Durán2, Michela Di Pierro3, Matteo Di Marino1, Carlo Nucci1,#br# Massimiliano Coletta3, Raffaele Mancino1#br#   

  1. 1 Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    2 Ophthalmic Research Unit “Santiago Grisolia”/FISABIO and Cellular-Molecular Ophthalmobiology Group/University of Valencia, Valencia, Spain
    3 Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy
  • Online:2020-02-15 Published:2020-05-25
  • Contact: Alessio Martucci, MD, PhD,alessio.martucci@live.it.

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摘要：

多巴胺及其受体已在神经病学和视网膜相关研究中受到广泛关注。为评估多巴胺在孔源性视网膜脱离中的可能作用，试验比较了孔源性视网膜脱离、黄斑褶皱与玻璃体出血患者玻璃体样本中视网膜多巴胺水平替代指数3,4-二羟基苯乙酸的量。结果显示，孔源性视网膜脱离患者玻璃体样本中3,4-二羟基苯乙酸水平显著高于玻璃体出血和黄斑褶皱患者。Pearson相关系数表明3,4-二羟基苯乙酸的含量与疾病诊断和手术之间的时间之间无相关性，但与孔源性视网膜脱离患者术后最佳矫正视力之间存在正相关关系。研究结果首次表明（1）3,4-二羟基苯乙酸在孔源性视网膜脱离后释放，但在其他视网膜疾病玻璃体出血和黄斑褶皱中未发现此现象；（2）视敏度结果与玻璃体内3,4-二羟基苯乙酸的量之间的相关性提示了3,4-二羟基苯乙酸在孔源性视网膜脱离发病机制和/或相关的光感受器损失中的意义。研究于2010年9月24日获得罗马Tor Vergata大学医院伦理委员会（R.S.92.10）的批准。

orcid: 0000-0002-3725-8211 (Alessio Martucci)

关键词: 多巴胺, 孔源性视网膜脱离, 氧化应激, 玻璃体出血, 黄斑皱纹, DOPAC, 3,4-二羟基苯乙酸, 光感受器变性, 多巴胺能无长突细胞, 多巴胺能神经毒性

Abstract: Dopamine and its receptors have been widely studied in the neurological conditions and in the retina. In this study, we evaluated the possible role of dopamine in rhegmatogenous retinal detachment (RRD) by comparing the amount of 3,4-dihydroxyphenylacetic acid (DOPAC), a surrogate index of retinal dopamine levels, in the vitreous sample of patients affected by RRD with those affected by macular pucker and vitreous hemorrhage. Our results showed that significantly higher levels of DOPAC were found in the vitreous sample of patients affected by RRD compared with those affected by vitreous hemorrhage and macular pucker (P = 0.002). Specifically, no trace of the substance was found in vitreous hemorrhage and macular pucker samples. A slightly significant positive correlation was found among DOPAC and post-operative best corrected visual acuity (r = 0.470, P = 0.049). No correlation was found between DOPAC and the days elapsed between diagnosis and surgery (P = 0.317). For the first time our findings suggest that DOPAC is released in RRD, but not in other retinal diseases such as vitreous hemorrhage and macular pucker. Moreover, we showed a correlation between visual acuity outcome and the amount of DOPAC in the vitreous. This might have a potential, although still unknown, implication in the pathogenesis of the disease and/or in the associated photoreceptors loss. This study was approved by the Ethics Committee of Rome Tor Vergata University Hospital (R.S.92.10) on September 24, 2010.

Key words: 3,4-dihydroxyphenylacetic acid, DOPAC, dopamine, dopaminergic amacrine cells, dopaminergic neurotoxicity, macular pucker, oxidative stress, photoreceptor degeneration, rhegmatogenous retinal detachment, vitreous hemorrhage