中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (6): 1210-1227.doi: 10.4103/1673-5374.325012

• 综述:退行性病与再生 • 上一篇    下一篇

条条大路通罗马：运动因子对阿尔茨海默病神经保护的潜在作用机制

  

  • 出版日期:2022-06-15 发布日期:2021-12-16

All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease

Yi-Yao Liang1, 2, #, Li-Dan Zhang1, 2, #, Xi Luo1, 2, Li-Li Wu3, 4, Zhao-Wei Chen5, Guang-Hao Wei5, Kai-Qing Zhang5, Ze-An Du6, Ren-Zhi Li7, Kwok-Fai So1, 2, 8, 9, *, Ang Li1, 2, 8, *   

  1. 1Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China; 2Key Laboratory of CNS Regeneration (Jinan University), Ministry of Education, Guangzhou, Guangdong Province, China; 3Department of Medical Ultrasonics, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China; 4Guangdong Key Laboratory of Liver Disease Research, Sun Yat-sen University, Guangzhou, Guangdong Province, China; 5Department of Clinical Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong Province, China; 6Department of Clinical Medicine, International School, Jinan University, Guangzhou, Guangdong Province, China; 7International Department of the Affiliated High School of South China Normal University, Guangzhou, Guangdong Province, China; 8Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, Guangdong Province, China; 9Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China
  • Online:2022-06-15 Published:2021-12-16
  • Contact: Kwok-Fai So, PhD, hrmaskf@hku.hk; Ang Li, MD, PhD, anglijnu@jnu.edu.cn.
  • Supported by:
    The work was supported by the National Natural Science Foundation of China, No. 82071372 (to AL); the Natural Science Foundation of Guangdong Province of China, No. 2021A1515011231 (to AL); Outstanding Scholar Program of Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) of China, No. 2018GZR110102002 (to KFS and AL); and Science and Technology Program of Guangzhou of China, No. 202007030012 (to KFS and AL).

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摘要： Neural Regen Res：运动对阿尔茨海默病的神经保护作用
来自中国暨南大学的李昂团队最新综述总结了运动诱导产生的运动因子（exerkine）对阿尔茨海默病潜在的治疗作用和相关分子机制，以期在传统疗法成本高、疗效差的情况下，为寻求新的经济、高效、个体化的干预手段提供思路。
作为最常见的神经退行性疾病之一，阿尔茨海默病的发病率随年龄增加呈指数型增长，且近年来发病人群有年轻化的趋势。大量研究表明体育锻炼有助于维持和改善大脑在认知、情绪、精神运动协调能力等方面的正常功能。运动可促进多种生物活性物质的释放，从而对阿尔茨海默病患者产生潜在的治疗效果。
因此李昂团队系统归纳了运动促进释放的生物活性物质（统称运动因子）对中枢神经系统保护作用的相关研究，并筛选了13种代表性运动因子进行详细阐述。文章将上述因子归为四大类，进一步总结其运动后的动态表达规律，并基于阿尔茨海默病的病理机制分析推测各自发挥保护效应的分子机制。这项工作有助于研究人员未来以运动因子作为切入点，发掘治疗阿尔茨海默病或其他神经退行性疾病的新靶标，以及为不同年龄、性别和健康状况的个体开发定制化的运动疗法。

这项成果撰写的文章发表在《中国神经再生研究（英文版）》杂志2022年6期。

https://orcid.org/0000-0003-4039-4246 (Kwok-Fai So); https://orcid.org/0000-0002-9886-4880 (Ang Li)

Abstract: Age-related neurodegenerative disorders such as Alzheimer’s disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, impractical, and expensive. Many studies have shown that a variety of bioactive substances released by physical exercise (called “exerkines”) help to maintain and improve the normal functions of the brain in terms of cognition, emotion, and psychomotor coordination. Increasing evidence suggests that exerkines may exert beneficial effects in AD as well. This review summarizes the neuroprotective effects of exerkines in AD, focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise. The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages, genders, and health conditions.

Key words: Alzheimer’s disease, amyloid beta, central nervous system, exerkine, neurodegeneration, neuroinflammation, neuroprotection, oxidative stress, physical exercise, Tau protein