中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (12): 2664-2665.doi: 10.4103/1673-5374.339478

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

各行其道——轴突中 RNA 复合物运输的不同模式

  

  • 出版日期:2022-12-15 发布日期:2022-05-05

Riding the rails – different modes for RNA complex transport in axons

Ofri Abraham, Mike Fainzilber*   

  1. Departments of Biomolecular Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel
  • Online:2022-12-15 Published:2022-05-05
  • Contact: Mike Fainzilber, PhD, mike.fainzilber@weizmann.ac.il.
  • Supported by:
    We gratefully acknowledge funding from the Israel Science Foundation (ISF 1337/18, to MF) and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (to MF). MF is the incumbent of the Chaya Professorial Chair in Molecular Neuroscience at the Weizmann Institute of Science. 

摘要: https://orcid.org/0000-0001-8173-8557 (Mike Fainzilber)

Abstract: Neurons are highly polarized cells with axons that innervate distant targets. The distance of subcellular compartments from the nucleus requires sophisticated transport mechanisms and local action of vital processes for proper function and rapid responses to local stimuli (Terenzio et al., 2017). This is partially achieved by transport of mRNAs to subcellular locations and regulation of local translation for axonal growth, branching, synaptic plasticity, and regeneration, among other needs. Axonally synthesized proteins support neuronal survival, and axonal development, maintenance, and growth (Rishal and Fainzilber, 2014; Dalla Costa et al., 2021). Thus, understanding the mechanisms that promote RNA transport to subcellular locations in neurons will contribute to the development of novel strategies to enhance axon regeneration and survival.