中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (2): 253-257.doi: 10.4103/1673-5374.343902

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

脑和脊髓创伤:我们对胰岛素生长因子 1 基因治疗的治疗潜力的了解

  

  • 出版日期:2023-02-15 发布日期:2022-08-05

Brain and spinal cord trauma: what we know about the therapeutic potential of insulin growth factor 1 gene therapy

María Jose Bellini1, Florencia Labombarda2, 3, *   

  1. 1Lab de Bioquímica del Envejecimiento, INIBIOLP- CONICET, Facultad de Ciencias Medicina, Universidad Nacional de La Plata, La Plata, Argentina; 2Laboratory of Neuroendocrine Biochemistry, IBYME-CONICET, Buenos Aires, Argentina; 3Department of Human Biochemistry, Faculty of Medicine, Universidad de Buenos Aires, Buenos Aires, Argentina
  • Online:2023-02-15 Published:2022-08-05
  • Contact: Florencia Labombarda, florlabombarda@gmail.com.
  • Supported by:
    This work was funded by grants PICT 2017 N° 0509 from Argentine Ministry of Science and Technology and PIP 2017-2019 N° 00301 from The National Research Council of Argentina granted to FL and the grant from The National Research Council of Argentina PIP 2014-2017 (extended to 2020) 0618 awarded to MJB. 

摘要: https://orcid.org/0000-0001-7911-1173 (Florencia Labombarda)

Abstract: Although little attention has been paid to cognitive and emotional dysfunctions observed in patients after spinal cord injury, several reports have described impairments in cognitive abilities. Our group also has contributed significantly to the study of cognitive impairments in a rat model of spinal cord injury. These findings are very significant because they demonstrate that cognitive and mood deficits are not induced by lifestyle changes, drugs of abuse, and combined medication. They are related to changes in brain structures involved in cognition and emotion, such as the hippocampus. Chronic spinal cord injury decreases neurogenesis, enhances glial reactivity leading to hippocampal neuroinflammation, and triggers cognitive deficits. These brain distal abnormalities are recently called tertiary damage. Given that there is no treatment for Tertiary Damage, insulin growth factor 1 gene therapy emerges as a good candidate. Insulin growth factor 1 gene therapy recovers neurogenesis and induces the polarization from pro-inflammatory towards anti-inflammatory microglial phenotypes, which represents a potential strategy to treat the neuroinflammation that supports tertiary damage. Insulin growth factor 1 gene therapy can be extended to other central nervous system pathologies such as traumatic brain injury where the neuroinflammatory component is crucial. Insulin growth factor 1 gene therapy could emerge as a new therapeutic strategy for treating traumatic brain injury and spinal cord injury.  

Key words: cognitive impairments, gene therapy, hippocampus, insulin growth factor 1, microglial cells, neurodegeneration, neurogenesis, neuroinflammation, spinal cord injury, traumatic brain injury