中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (2): 416-421.doi: 10.4103/1673-5374.346549

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

双去甲氧基姜黄素可治疗辐射性脑损伤

  

  • 出版日期:2023-02-15 发布日期:2022-08-09
  • 基金资助:
    国家自然科学基金项目(82002400);湖南省卫健委科研项目(20201911,20200469,20211411761);湖南省自然科学基金项目(2020JJ5512);湖南省临床医学技术创新指导项目(2020SK51822)

Treatment of radiation-induced brain injury with bisdemethoxycurcumin

Yun-Qian Chang1, 2, #, Gui-Juan Zhou1, #, Hong-Mei Wen3, Duan-Qun He1, 4, Chen-Lin Xu1, 5, Ya-Rui Chen1, Yi-Hui Li1, Shuang-Xi Chen1, *, Zi-Jian Xiao1, *, Ming Xie1, *   

  1. 1Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China; 2Department of Neurology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China; 3Department of Nursing, Youxian People’s Hospital, Zhuzhou, Hunan Province, China; 4Department of Neurology, Shenzhen Baoan People’s Hospital (Group), The Second People’s Hospital, Shenzhen, Guangdong  Province, China; 5Department of Neurology, Xiangxi Autonomous Prefecture People’s Hospital, Jishou, Hunan Province, China
  • Online:2023-02-15 Published:2022-08-09
  • Contact: Ming Xie, PhD, c237423281@163.com; Zi-Jian Xiao, PhD, zijian6340@21cn.com; Shuang-Xi Chen, PhD, dnafenzi@163.com.
  • Supported by:
    The study was supported by the National Natural Science Foundation of China, No. 82002400 (to GJZ); Scientific Research Project of Hunan Health Committee, No. 20201911 and No. 20200469 (both to ZJX); Scientific Research Project of Hunan Health Committee, No. 20211411761 (to HMW); the Natural Science Foundation of Hunan Province, No. 2020JJ5512 (to GJZ); a grant from Clinical Medical Technology Innovation Guidance Project in Hunan Province, No. 2020SK51822 (to ZJX).

摘要:

放疗被认为是治疗脑肿瘤的最有效的非手术性疗法,但放疗可能引发辐射性脑损伤,导致患者产生进行性认知功能障碍,目前仍无针对这种脑损伤的有效治疗方法。双去甲氧基姜黄素是姜黄素的一种脱甲氧基衍生物,有抗增殖、抗炎和抗氧化特性。为验证双去甲氧基姜黄素是否具有治疗辐射性脑损伤的潜力,实验以单次30 Gy全脑垂直照射建立了辐射性脑损伤大鼠模型,而后连续5周腹腔注射500 μL 100mg/kg双去甲氧基姜黄素进行治疗。结果显示,双去甲氧基姜黄素可增加辐射性脑损伤大鼠体质量,改善辐射性脑损伤大鼠学习和记忆能力,同时可减轻脑水肿,抑制星形胶质细胞活化,还能降低辐射性脑损伤后氧化应激。表明双去甲氧基姜黄素可对辐射性脑损伤具有保护作用。

https://orcid.org/0000-0002-0278-1408 (Ming Xie); https://orcid.org/0000-0001-5137-9549 (Zi-Jian Xiao); https://orcid.org/0000-0001-7711-9171 (Shuang-Xi Chen)

关键词: 辐射治疗, 脑肿瘤, 辐射性脑损伤, 双去甲氧基姜黄素, 姜黄素, 学习, 记忆, 脑水肿, 星形胶质细胞, 氧化应激, 神经元损伤

Abstract: Radiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidant properties. To determine whether BDMC has the potential to treat radiation-induced brain injury, in this study, we established a rat model of radiation-induced brain injury by administering a single 30-Gy vertical dose of irradiation to the whole brain, followed by intraperitoneal injection of 500 μL of a 100 mg/kg BDMC solution every day for 5 successive weeks. Our results showed that BDMC increased the body weight of rats with radiation-induced brain injury, improved learning and memory, attenuated brain edema, inhibited astrocyte activation, and reduced oxidative stress. These findings suggest that BDMC protects against radiation-induced brain injury.

Key words: astrocytes, bisdemethoxycurcumin, brain edema, brain tumor, curcumin, learning and memory, neuronal injury, oxidative stress, radiation therapy, radiation-induced brain injury