中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (on line): 1-7.doi: 10.4103/1673-5374.353485

• •    下一篇

Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events

  

  • 出版日期:2023-01-01 发布日期:2022-08-18

Zhen-Xiao Ren1, Jing-Hui Xu1, Xing Cheng1, Gui-Xing Xu2, Hou-Qing Long1, *   

  1. 1Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology/ Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China; 2Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China
  • Online:2023-01-01 Published:2022-08-18
  • Contact: Hou-Qing Long, MD, houqinglong@163.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81450020 (to HQL).

摘要: https://orcid.org/0000-0003-4306-2319 (Hou-Qing Long)

Abstract: Cervical spondylotic myelopathy is the main cause of non-traumatic spinal cord injury, with chronic static and/or dynamic compressive spinal cord injury as the unique pathogenesis. In the progression of this condition, the microvascular network is compressed and destroyed, resulting in ischemia and hypoxia. The main pathological changes are inflammation, damage to the blood spinal cord barriers, and cell apoptosis at the site of compression. Studies have confirmed that vascular regeneration and remodeling contribute to neural repair by promoting blood flow and the reconstruction of effective circulation to meet the nutrient and oxygen requirements for nerve repair. Surgical decompression is the most effective clinical treatment for this condition; however, in some patients, residual neurological dysfunction remains after decompression. Facilitating revascularization during compression and after decompression is therefore complementary to surgical treatment. In this review, we summarize the progress in research on chronic compressive spinal cord injury, covering both physiological and pathological changes after compression and decompression, and the regulatory mechanisms of vascular injury and repair.

Key words: angiogenesis, cervical spondylotic myelopathy, hypoxia, inflammation, ischemia, spinal cord injury, surgical decompression