中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (7): 1404-1410.doi: 10.4103/1673-5374.360273

• 综述:退行性病与再生 • 上一篇    下一篇

新冠肺炎后的阿尔茨海默病风险:从神经退行性传染假说角度看

  


  • 出版日期:2023-07-15 发布日期:2023-01-11

Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration

Eugenia Olivera, Albany Sáez, Lila Carniglia, Carla Caruso, Mercedes Lasaga, Daniela Durand*   

  1. Instituto de Investigaciones Biomédicas INBIOMED UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Argentina
  • Online:2023-07-15 Published:2023-01-11
  • Contact: Daniela Durand, PhD, ddurand@fmed.uba.ar.
  • Supported by:
    This work was supported by grants to DD from Agencia Nacional de Promoción de la Investigación, el desarrollo tecnológico y la innovación (ANPCyT, PICT N°03893).

摘要: https://orcid.org/0000-0003-2361-1165 (Daniela Durand)

Abstract: In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration, we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration. We wondered how SARS-CoV-2 could be related to the amyloid-β cascade and how it could lead to the pathological hallmarks of the disease. We also predict a paradigm change in clinical medicine, which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.

Key words: Alzheimer, amyloid beta, antimicrobial, cognitive decline, COVID-19, infectious hypothesis, long-term sequelae, neurodegeneration, neuroinflammation, neurological symptoms, neurotropism, SARS-CoV-2