中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1707-1708.doi: 10.4103/1673-5374.363829

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

老年肠道微生物群与缺血性中风的大脑之间的串联

  

  • 出版日期:2023-08-15 发布日期:2023-02-16

Gut microbiota neurotransmitters: influence on risk and outcome of ischemic stroke

Ryszard Pluta*, Sławomir Januszewski   

  1. Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
  • Online:2023-08-15 Published:2023-02-16
  • Contact: Ryszard Pluta, MD, PhD, pluta@imdik.pan.pl.
  • Supported by:
    The authors acknowledge the financial support from the Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (T3-RP) (to RP).

摘要: https://orcid.org/0000-0003-0764-1356 (Ryszard Pluta)

Abstract: Ischemic stroke: Stroke is the second and third cause of death and disability, respectively, with an annual rate of 24.9 million cases worldwide (Chidambaram et al., 2022). Stroke is defined as the lack of blood supply to a specific area of the brain, accounting for 85% of all cases (Chidambaram et al., 2022). Changes in the gut microbiota have also been reported as risk factor for stroke (Pluta et al., 2021; Tan et al., 2021; Chidambaram et al., 2022). Post-stroke neurodegeneration is multifactorial characterized by neuronal death, amyloid plaques, neurofibrillary tangles, a neuroinflammatory response, a lack of acetylcholine, and a cognitive deficit with full-blown dementia (approximately 50% survivors) (Yuan et al., 2020; Pluta 2022).