中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (12): 2592-2598.doi: 10.4103/1673-5374.373672

• 综述:退行性病与再生 • 上一篇    下一篇

黑匣子之外的思考:脑内皮细胞是阿尔茨海默病的新主要靶点吗?

  

  • 出版日期:2023-12-15 发布日期:2023-06-14

Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer’s disease?

Enrique Estudillo1, *, #, Adolfo López-Ornelas2, 3, #, Alejandro Rodríguez-Oviedo4, Neptali Gutiérrez de la Cruz5, 6, #br# Marco Antonio Vargas-Hernández6, Adriana Jiménez2, *#br#   

  1. 1Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico; 2División de Investigación, Hospital Juárez de México, Mexico City, Mexico; 3Hospital Nacional Homeopático, Hospitales Federales de Referencia, Mexico City, Mexico; 4Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico; 5Laboratorio de Morfología, Escuela Militar de Graduados de Sanidad, Secretaría de la Defensa Nacional, Batalla de Celaya, Lomas de Sotelo, Miguel Hidalgo, Mexico City, Mexico; 6Escuela Militar de Graduados de Sanidad, Secretaría de la Defensa Nacional, Batalla de Celaya, Lomas de Sotelo, Miguel Hidalgo, Mexico City, Mexico
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Enrique Estudillo, MSc, PhD, jestudillo@innn.edu.mx; Adriana Jiménez, PhD, adijh@hotmail.com.
  • Supported by:

摘要: https://orcid.org/0000-0001-7918-2617 (Enrique Estudillo); https://orcid.org/0000-0001-5742-3985 (Adriana Jiménez) 

Abstract: The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of transport. Although brain endothelial cell function is crucial for brain homeostasis, their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia, astroglia, neurons, or even molecules such as amyloid beta, Tau, or alpha-synuclein. Alzheimer’s disease is the most common neurodegenerative disease, and brain endothelial cell dysfunction has been reported by several groups. However, its impairment has barely been considered as a potential therapeutic target. Here we review the most recent advances in the relationship between Alzheimer’s disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease, highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ailment. Finally, we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer’s disease.

Key words: dementia, endothelial cells, neurodegeneration, neuroinflammation, neuronal death, paracellular transport, transcellular transport