中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (2): 342-349.doi: 10.4103/1673-5374.379017

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

环状RNAs在神经系统中的生理和病理功能

  

  • 出版日期:2024-02-15 发布日期:2023-08-30
  • 基金资助:
    国家自然科学基金;重庆市青年英才计划;重庆市留学回国人员创新支持计划;重庆市自然科学基金

Physiological and pathological functions of circular RNAs in the nervous system

Min Zhou, Shi Li, Chuan Huang*   

  1. School of Life Sciences, Chongqing University, Chongqing, China
  • Online:2024-02-15 Published:2023-08-30
  • Contact: Chuan Huang, PhD, chuanhuang@cqu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 32270601 and 32070633 (to CH), the Chongqing Talents Plan for Young Talents No. cstc2022ycjh-bgzxm0140 (to CH), the Innovation Support Program for Overseas Returned Scholars of Chongqing, China, No. cx2019142 (to CH), and the Natural Science Foundation of Chongqing of China, No. cstc2021jcyj-bshX0121 (to MZ).

摘要:

环状RNAs是一类共价闭合单链RNA分子,具有细胞/组织/发育特异性表达等特征。环状RNAs通过吸附microRNAs,调节基因转录,控制某些RNA结合蛋白的活性,以及产生功能肽等机制在生理和病理过程中发挥着至关重要的作用。环状RNAs在神经系统中的功能是目前研究的热点之一。文章首先总结了最近环状RNAs在大脑发育、成熟和衰老中的作用。然后,重点讨论了环状RNAs在各种中枢神经系统疾病,如:慢性神经退行性疾病和急性神经系统损伤以及神经病理性疼痛中的生理和病理功能。了解环状RNAs的功能将有助于制定治疗神经系统疾病的潜在诊断、预后和治疗策略。

https://orcid.org/0000-0003-2565-9154 (Chuan Huang)

Abstract: Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and tissues. CircRNAs play crucial roles in physiological and pathological processes by sponging microRNAs, modulating gene transcription, controlling the activity of certain RNA-binding proteins, and producing functional peptides. A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 years. However, the precise role of circRNAs in the nervous system has yet to be comprehensively reviewed. In this review, we first summarize the recently described roles of circRNAs in brain development, maturity, and aging. Then, we focus on the involvement of circRNAs in various diseases of the central nervous system, such as brain cancer, chronic neurodegenerative diseases, acute injuries of the nervous system, and neuropathic pain. A better understanding of the functionality of circRNAs will help us to develop potential diagnostic, prognostic, and therapeutic strategies to treat diseases of the nervous system.

Key words: Alzheimer’s disease, amyotrophic lateral sclerosis, brain development, circRNAs, neuropathic pain, Parkinson’s disease