中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (7): 1523-1531.doi: 10.4103/1673-5374.387966

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

微小RNA作为诊断精神分裂症的潜在生物标志物及抗精神病药物治疗的影响

  

  • 出版日期:2024-07-15 发布日期:2023-11-28

MicroRNAs as potential biomarkers for diagnosis of schizophrenia and influence of antipsychotic treatment

Bridget Martinez1, 2, Philip V. Peplow3, *   

  1. 1Department of Pharmacology, University of Nevada-Reno, Reno, NV, USA; 2Department of Medicine, University of Nevada-Reno, Reno, NV, USA; 3Department of Anatomy, University of Otago, Dunedin, New Zealand
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Philip V. Peplow, PhD, pvpeplow@gmail.com.

摘要: https://orcid.org/0000-0001-5468-1989 (Philip V. Peplow)

Abstract: Characterized by positive symptoms (such as changes in behavior or thoughts, including delusions and hallucinations), negative symptoms (such as apathy, anhedonia, and social withdrawal), and cognitive impairments, schizophrenia is a chronic, severe, and disabling mental disorder with late adolescence or early adulthood onset. Antipsychotics are the most commonly used drugs to treat schizophrenia, but those currently in use do not fully reverse all three types of symptoms characterizing this condition. Schizophrenia is frequently misdiagnosed, resulting in a delay of or inappropriate treatment. Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of schizophrenia. The recent studies reviewed included microRNA profiling in blood- and urine-based materials and nervous tissue materials. From the studies that had validated the preliminary findings, potential candidate biomarkers for schizophrenia in adults could be miR-22-3p, -30e-5p, -92a-3p, -148b-5p, -181a-3p, -181a-5p, -181b-5p, -199b-5p, -137 in whole blood, and miR-130b, -193a-3p in blood plasma. Antipsychotic treatment of schizophrenia patients was found to modulate the expression of certain microRNAs including miR-130b, -193a-3p, -132, -195, -30e, -432 in blood plasma. Further studies are warranted with adolescents and young adults having schizophrenia and consideration should be given to using animal models of the disorder to investigate the effect of suppressing or overexpressing specific microRNAs.

Key words: antipsychotics, biomarkers, blood exosomes, blood plasma, brain tissue exosomes, brain tissues, leukocytes, microRNAs, neural stem cells, olfactory neuroepithelium, schizophrenia, whole blood