中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1768-1771.doi: 10.4103/1673-5374.389359

• 综述:退行性病与再生 • 上一篇    下一篇

人体和多发性硬化症临床前模型的体育锻炼和突触保护

  

  • 出版日期:2024-08-15 发布日期:2024-01-03

Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis

Federica Azzolini1, Ettore Dolcetti1, Antonio Bruno1, Valentina Rovella2, Diego Centonze1, 3, *, Fabio Buttari1, 3   

  1. 1Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy; 2Department of System Medicine, University of Tor Vergata, Rome, Italy; 3Synaptic Immunopathology Lab, Department of Systems Medicine, Tor Vergata University, Rome, Italy
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Diego Centonze, MD, PhD, centonze@uniroma2.it or diego.centonze@neuromed.it.

摘要: https://orcid.org/0000-0002-8390-8545 (Diego Centonze)

Abstract: In multiple sclerosis, only immunomodulatory and immunosuppressive drugs are recognized as disease-modifying therapies. However, in recent years, several data from pre-clinical and clinical studies suggested a possible role of physical exercise as disease-modifying therapy in multiple sclerosis. Current evidence is sparse and often conflicting, and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully elucidated. Data, mainly derived from pre-clinical studies, suggest that exercise could enhance long-term potentiation and thus neuroplasticity, could reduce neuroinflammation and synaptopathy, and dampen astrogliosis and microgliosis. In humans, most trials focused on direct clinical and MRI outcomes, as investigating synaptic, neuroinflammatory, and pathological changes is not straightforward compared to animal models. The present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies. 

Key words: disease-modifying behaviour, endocannabinoid system, long-term potentiation, multiple sclerosis, neuroplasticity, neuroprotection, physical exercise, synaptopathy