中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (8): 1759-1767.doi: 10.4103/1673-5374.389631

• 综述:退行性病与再生 • 上一篇    下一篇

前额叶皮质多巴胺在帕金森病执行功能中起着多方面的作用

  

  • 出版日期:2024-08-15 发布日期:2024-01-03
  • 基金资助:
    国家自然科学基金项目(82101263);江苏省青年科学基金项目(BK20210903);徐州医科大学优秀学者研究基金项目(RC20552114)

Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson’s disease

Zihang Zhou#, Yalong Yan#, Heng Gu, Ruiao Sun, Zihan Liao, Ke Xue, Chuanxi Tang*   

  1. Department of Neurobiology, Xuzhou Key Laboratory of Neurobiology, Xuzhou Medical University, Xuzhou, Jiangsu Province, China
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Chuanxi Tang, PhD, chxtang@xzhmu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 82101263; Jiangsu Province Science Foundation for Youths, No. BK20210903; and Research Foundation for Talented Scholars of Xuzhou Medical University, No. RC20552114 (all to CT)

摘要:

帕金森病不仅会影响运动,还会影响思维能力,即认知功能障碍。帕金森病认知功能障碍的一个常见问题是执行功能困难。执行功能可帮助我们根据目标规划、组织和控制自身行为。负责执行功能的大脑区域被称为前额叶皮质,其就像大脑的指挥中心,尤其是在调节执行功能时。前额叶皮质在认知过程中的作用受到一种名为多巴胺的化学信使的影响。然而目前仍然不太了解多巴胺如何影响帕金森病的认知功能。此次综述回顾了关于这一主题的最新研究。文章首先总结多巴胺能系统(包括多巴胺)如何在帕金森病中执行功能中发生了变化;然后探索了多巴胺的变化如何影响前额叶皮质的突触结构、电活动和连接成分;最后还考虑了总结了帕金森病和多巴胺相关认知问题之间的关系,这可能为进一步研究和改进帕金森病认知障碍的临床治疗提供有价值的线索。

https://orcid.org/0000-0002-5500-8419 (Chuanxi Tang); https://orcid.org/0000-0003-2404-0720 (Zihang Zhou)

关键词: 帕金森病, 前额叶皮质, 执行功能, 多巴胺, 多巴胺转运蛋白, 神经网络, 神经振荡, 突触可塑性, 多巴胺受体, 神经网络

Abstract: Parkinson’s disease can affect not only motor functions but also cognitive abilities, leading to cognitive impairment. One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive functioning. Executive functions help us plan, organize, and control our actions based on our goals. The brain area responsible for executive functions is called the prefrontal cortex. It acts as the command center for the brain, especially when it comes to regulating executive functions. The role of the prefrontal cortex in cognitive processes is influenced by a chemical messenger called dopamine. However, little is known about how dopamine affects the cognitive functions of patients with Parkinson’s disease. In this article, the authors review the latest research on this topic. They start by looking at how the dopaminergic system, is altered in Parkinson’s disease with executive dysfunction. Then, they explore how these changes in dopamine impact the synaptic structure, electrical activity, and connection components of the prefrontal cortex. The authors also summarize the relationship between Parkinson’s disease and dopamine-related cognitive issues. This information may offer valuable insights and directions for further research and improvement in the clinical treatment of cognitive impairment in Parkinson’s disease.

Key words: dopamine, dopamine receptor, dopamine transporter, executive dysfunction, neural network, neural oscillation, prefrontal cortex, synaptic plasticity