中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (5): 1445-1454.doi: 10.4103/NRR.NRR-D-23-01101

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

运动预处理通过提高循环脂联素水平减轻脑缺血诱导的记忆功能障碍

  

  • 出版日期:2025-05-15 发布日期:2024-10-31
  • 基金资助:
    STI2030-重大项目，2022ZD0207600；国家自然科学基金，32070955，U22A20301；广东省自然科学基金，2021A1515012197；广州市医学核心学科项目，2021-2023；宁夏回族自治区重点研发计划，2022-2023，2021A1515012197; 广州医学核心学科项目，2021-2023; 宁夏回族自治区重点研发计划，2022BEG01004; 广州市科技计划，202007030012

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

Meifeng Zheng1, 2, 3, # , Borui Zhang3, # , Sonata S Y Yau4 , Kwok-Fai So3, 5, 6, 7 , Li Zhang3, 6, 7, * , Haining Ou1, 2, *   

  1. 1 Department of Rehabilitatton Medicine, Guangzhou Medical University, Guangzhou, Guangdong Province, China;  2 Department of Rehabilitatton Medicine, The Fiffh Clinical College of Guangzhou Medical University, Guangzhou, Guangdong Province, China;  3 Key Laboratory of CNS Regeneratton (Ministry of Educatton), Guangdong-Hong Kong-Macau Instttute of CNS Regeneratton, Jinan University, Guangzhou, Guangdong Province, China;  4 Department of Rehabilitatton Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrattve Region, China;  5 State Key Laboratory of Brain and Cognittve Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrattve Region, China;  6 Center for Exercise and Brain Science, School of Psychology, Shanghai University of Sport, Shanghai, China;  7 Neuroscience and Neurorehabilitatton Instttute, University of Health and Rehabilitatton Sciences, Qingdao, Shandong Province, China
  • Online:2025-05-15 Published:2024-10-31
  • Contact: Li Zhang, PhD, zhangli@jnu.edu.cn; Haining Ou, MD, ouhaining@gzhmu.edu.cn.
  • Supported by:
    This study was supported by STI2030-Major Projects, No. 2022ZD0207600 (to LZ); the Nattonal Natural Science Foundatton of China, Nos. 32070955 (to LZ), U22A20301 (to KFS); the Natural Science Foundatton of Guangdong Province, No. 2021A1515012197 (to HO); Guangzhou Core Medical Disciplines Project, No. 2021-2023 (to HO); Key Research and Development Plan of Ningxia Hui Automomous Region, No. 2022BEG01004 (to KFS); Science and Technology Program of Guangzhou, China, No. 202007030012 (to KFS and LZ).

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摘要：

研究表明，体育锻炼能有效改善神经发生和突触生成。脂联素可通过介导炎症小体通路、减轻氧化应激，以及改善脑血管功能，起到减轻脑缺血损害的作用。然而，目前还没有研究直接探讨脂联素在脑缺血情况下的运动干预中的作用。为了解运动预处理能否减轻脑缺血的严重程度，以及循环脂联素在其中的作用。实验在给予成年小鼠在大脑中动脉闭塞（MCAO）建立脑缺血模型前进行为期14天的跑步机运动训练。结果发现，运动预处理可有效缩小脑缺血小鼠脑梗死区，抑制胶质细胞生成，保护突触蛋白，改善认知和空间记忆。进一步分析表明，循环脂联素在运动的预防作用中起着至关重要的作用，激活脂联素受体可以增强运动的效果，而抑制受体激活则可以消除运动的效果。综上所述，循环脂联素在运动预处理对脑缺血的神经保护作用中有扮演重要角色。

https://orcid.org/0000-0003-1489-0879 (Li Zhang); https://orcid.org/0000-0003-4182-3081 (Haining Ou)

Abstract:

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy. Physical exercise enhances neurogenesis and synaptogenesis, and has been widely used for functional rehabilitation after stroke. In this study, we determined whether exercise training before disease onset can alleviate the severity of cerebral ischemia. We also examined the role of exercise-induced circulating factors in these effects. Adult mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery occlusion. We found that this exercise pre-conditioning strategy effectively attenuated brain infarct area, inhibited gliogenesis, protected synaptic proteins, and improved novel object and spatial memory function. Further analysis showed that circulating adiponectin plays a critical role in these preventive effects of exercise. Agonist activation of adiponectin receptors by AdipoRon mimicked the effects of exercise, while inhibiting receptor activation abolished the exercise effects. In summary, our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

Key words:

adiponectin, cerebral ischemia, exercise pre-conditioning, hippocampus, memory function, middle cerebral artery occlusion, prefrontal cortex, synaptic proteins, treadmill exercise