中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 184-185.doi: 10.4103/NRR.NRR-D-23-01637

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

ATP在视神经脊髓炎急性疼痛和周围神经性疼痛中的作用比较

  

  • 出版日期:2025-01-15 发布日期:2024-01-15

Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain

Teruyuki Ishikura, Tatsusada Okuno*   

  1. Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan (Ishikura T) 
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan (Okuno T)
  • Online:2025-01-15 Published:2024-01-15
  • Contact: Tatsusada Okuno, MD, PhD, okuno@neurol.med.osaka-u.ac.jp.

摘要: https://orcid.org/0000-0002-1208-936X (Tatsusada Okuno)

Abstract: In this article, we present our previous research, which highlighted adenosine triphosphate (ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder (NMOSD). In NMOSD pathology, damage-associated molecular patterns (DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD. We delve into the mechanisms of ATP in peripheral neuropathic pain, drawing comparisons with our findings in NMOSD. Additionally, we address the intricacies of chronic pain associated with NMOSD.