中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 197-198.doi: 10.4103/NRR.NRR-D-23-01966

• 观点:退行性病与再生 • 上一篇    下一篇

线粒体功能障碍中的α-突触核蛋白:机遇还是障碍

  

  • 出版日期:2025-01-15 发布日期:2025-01-15

Alpha-synuclein in mitochondrial dysfunction: opportunities or obstacles

Shermali Gunawardena*   

  1. Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Shermali Gunawardena, PhD, sg99@buffalo.edu.

摘要: https://orcid.org/0000-0001-8776-9397 (Shermali Gunawardena)

Abstract: Recent work suggests a link between α-synuclein (α-syn) and mitochondrial dysfunction; however, the mechanisms of how α-syn influences mitochondrial function are still unclear. Most notably, whether α-syn plays a direct role during mitochondrial function and/or whether diseased α-syn-mediated mitochondrial dysfunction is a potential modifiable risk factor in Parkinson’s disease (PD) is unknown.