中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 193-194.doi: 10.4103/NRR.NRR-D-23-02055

• 观点:退行性病与再生 • 上一篇    下一篇

神经肌肉接头在衰老和疾病中的再生机制和治疗策略

  

  • 出版日期:2025-01-15 发布日期:2025-01-15

Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

Masashi Fujitani*, Abu Md Mamun Tarif, Yoshinori Otani   

  1. Department of Anatomy and Neuroscience, Faculty of Medicine, Shimane University, Shimane, Japan
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Masashi Fujitani, MD, PhD, fujitani@med.shimane-u.ac.jp.
  • Supported by:
    This work was funded by the Japan Society for the Promotion of Science, JSPS, 23K07290 (to MF).

摘要: https://orcid.org/0000-0002-1731-9793 (Masashi Fujitani)

Abstract: The neuromuscular junction (NMJ) is an essential synaptic structure composed of motor neurons, skeletal muscles, and glial cells that orchestrate the critical process of muscle contraction (Li et al., 2018). The typical NMJ structure is classically described as having a “pretzel-like” shape in mice (Figure 1), whereas human NMJs have a smaller, fragmented structure throughout adulthood. Degenerated NMJs exhibit smaller or fragmented endplates, partial denervation, reduced numbers of synaptic vesicles, abnormal presynaptic mitochondria, and dysfunctional perisynaptic Schwann cells (Alhindi et al., 2022).