中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (4): 1085-1086.doi: 10.4103/NRR.NRR-D-24-00131

• 观点:退行性病与再生 • 上一篇    下一篇

新型葡糖脑苷酶抗体可推进神经退行性疾病领域的研究

  

  • 出版日期:2025-04-15 发布日期:2024-07-01

New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

Charis Ma# , Krystyna Rytel# , Yu Chen, Ellen Sidransky*   

  1. Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
  • Online:2025-04-15 Published:2024-07-01
  • Contact: Ellen Sidransky, MD, sidranse@nih.gov.

摘要: https://orcid.org/0000-0002-3019-8500 (Ellen Sidransky)

Abstract: In medical research, there are times when the introduction of a new tool can launch scientific discovery in new directions. While antibody development may be considered mundane, in the field of glucocerebrosidase (GCase) research, the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic development. The recent introduction of new, rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease (PD) as well as aspects of the pathobiology of Gaucher disease (Jong et al., 2024).