中国神经再生研究(英文版) ›› 2024, Vol. 20 ›› Issue (2): 483-484.doi: 10.4103/NRR.NRR-D-24-00189

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

细胞外小泡的性别依赖性改变将慢性脊髓损伤与脑神经炎症和神经退行性变联系起来

  

  • 出版日期:2025-02-15 发布日期:2024-06-18

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

Yun Li*, Junfang Wu*   

  1. Department of Anesthesiology & Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD, USA
  • Online:2025-02-15 Published:2024-06-18
  • Contact: Junfang Wu, MD, PhD,Junfang.wu@som.umaryland.edu; Yun Li, PhD,yun.li@som.umaryland.edu.
  • Supported by:
    This work was supported by NIH funding (RF1NS110637, 2RF1NS094527, and R01NS110635) to JW.

摘要:

https://orcid.org/0000-0003-3338-7291 (Junfang Wu)
https://orcid.org/0000-0003-2040-4451 (Yun Li)

Abstract: Traumatic spinal cord injury (SCI) is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability worldwide. Advances in assistive technology, rehabilitative interventions, and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients, with some people even living well into their seventh or eighth decade. These survival changes have led neurotrauma researchers to examine how SCI interacts with brain aging. Public health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life, along with a higher risk of comorbidities and complications. Although extensive effort has been spent on promoting the recovery of locomotor and sensory functions, little research has focused on pathophysiological changes in the brain. One of the long-term consequences of SCI is neuropsychological impairment, which includes deficits in memory, executive functions, attention span, processing speed, and learning abilities. Clinical studies show that SCI patients are more likely to be diagnosed with depression, anxiety, dementia, and other neurological disorders of the brain (Craig et al., 2017; Sachdeva et al., 2018; Distel et al., 2020). In fact, one study showed that SCI patients are 13 times more likely to show cognitive and emotional deficits (Craig et al., 2017). These reported cognitive impairments and mood disorders will not only compromise SCI patients’ quality of life and prognosis but also have deleterious effects on rehabilitation and recovery. However, despite these serious implications, few studies have focused on the underlying mechanisms of brain dysfunctions following SCI.