中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (5): 1395-1396.doi: 10.4103/NRR.NRR-D-24-00281

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

胶质细胞到神经元的重新编程拯救了它?

  

  • 出版日期:2025-05-15 发布日期:2024-10-30

Glia-to-neuron reprogramming to the rescue?

Jack W. Hickmott, Cindi M. Morshead*   

  1. Department of Surgery, University of Toronto, Toronto, ON, Canada (Hickmott JW, Morshead CM) Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON, Canada (Hickmott JW, Morshead CM)  Instttute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada (Morshead CM) The KITE Research Instttute, Toronto Rehabilitatton Instttute, University Health Network, Toronto, ON, Canada (Morshead CM) 
  • Online:2025-05-15 Published:2024-10-30
  • Contact: Cindi M. Morshead, PhD,cindi.morshead@utoronto.ca.
  • Supported by:
    This work was supported by Canada First Research Excellence Fund, Medicine by Design (to CMM). 

摘要: https://orcid.org/0000-0003-4605-4883 (Cindi M. Morshead); https://orcid.org/0000-0003-3764-1138 (Jack W. Hickmott)

Abstract: Over the last two decades, the dogma that cell fate is immutable has been increasingly challenged, with important implications for regenerative medicine. The breakthrough discovery that induced pluripotent stem cells could be generated from adult mouse ffbroblasts is powerful proof that cell fate can be changed. An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogramming hypothesis – that terminally differentiated cells can be reprogrammed into other adult cell fates without ffrst passing through a stem cell state. A significant body of evidence demonstrates direct cellular reprogramming in vitro (Vasan et al., 2021; Bocchi et al., 2022) and an excittng applicatton of this technology is the use of direct cellular reprogramming in vivo. Indeed, the promise of direct cellular reprogramming to replace lost cells in the central nervous system following neurotrauma or neurodegenerative disease is remarkable. Here we will discuss the hope, the hype, and the scrutiny that surrounds the promise of direct cellular reprogramming, specifically related to the generation of induced neurons from glial cells in vivo. We will highlight successes in the field, examine criticisms of this body of literature, and draw on previous examples of scienttffc controversy to propose a path forward to “rescue” the ffeld.