中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (12): 3517-3518.doi: 10.4103/NRR.NRR-D-24-00831

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

神经元自噬:自噬自我毁灭与缺氧缺血性神经元死亡相关

  

  • 出版日期:2025-12-15 发布日期:2025-03-15

Neuronal autosis: the selfdestructive side of autophagy involved in hypoxic-ischemic neuronal death

Vanessa Ginet# , Pauline Depierre# , Julien Puyal*   

  1. Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland (Ginet V, Depierre P, Puyal J) Clinic of Neonatology, Department of Women, Mother and Child, University Hospital Center of Vaud, Lausanne, Switzerland (Ginet V) CURML, University Center of Legal Medicine, Lausanne University Hospital, Lausanne, Switzerland (Puyal J)
  • Online:2025-12-15 Published:2025-03-15
  • Contact: Julien Puyal, PhD, julienpierre.puyal@unil.ch.
  • Supported by:
    This work was supported by grants from the Swiss National Science Foundation (310030-182332 and 310030L-208141) (to JP).

摘要: https://orcid.org/0000-0002-8140-7026  (Julien Puyal)

Abstract: The challenge of protecting the brain resides in the unique characteristics of neurons, as they are postmitotic, long-lived, excitable, and polarized cells with long and fragile axons and dendrites. The complexity of the multiple potential cell death pathways further complicates this issue. In addition, the immature brain is prone to a “cell death continuum,” which involves intricate molecular interconnections between cell death processes. This makes finding safe and effective neuroprotective strategies to prevent damage to the developing brain a significant challenge in neonatology. The only approved treatment for term newborns with hypoxic-ischemic encephalopathy (HIE) is therapeutic hypothermia. However, access to this treatment and its effectiveness is limited to a few cases. Research is focused on developing new neuroprotective agents that can be combined with hypothermia to improve its therapeutic window and outcome.