中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 1116-1117.doi: 10.4103/NRR.NRR-D-24-01171

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

CD40L -反向信号对树突和轴突生长和分枝的调节:JNK, PKC和ERK1/2信号通路的相互关系

  

  • 出版日期:2026-03-15 发布日期:2025-07-04

Regulation of dendrite and axon growth and arborization by CD40Lreverse signaling: Interrelationships among JNK, PKC, and ERK1/2 signaling pathways

Paulina Carriba*, †   

  1. School of Biosciences, Cardiff University, Cardiff, Wales, UK †Current address: Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain Department of Biomedicine, Universitat de Vic, Vic, Spain
  • Online:2026-03-15 Published:2025-07-04
  • Contact: Paulina Carriba, PhD, paulina.carriba@gmail.com.
  • Supported by:
    This work was supported by the Wellcome Trust (grant No. 103852).

摘要: https://orcid.org/0000-0002-6980-2277 (Paulina Carriba)

Abstract: The nervous system function requires a precise but plastic neural architecture. The neuronal shape dictates how neurons interact with each other and with other cells, being the morphology of dendrites and axons the central determinant of the functional properties of neurons and neural circuits. The topological and structural morphology of axons and dendrites defines and determines how synapses are conformed. The morphological diversity of axon and dendrite arborization governs the neuron’s inputs, synaptic integration, neuronal computation, signal transmission, and network circuitry, hence defining the particular connectivity and function of the different brain areas.