中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (6): 2361-2362.doi: 10.4103/NRR.NRR-D-25-00569

• 观点:退行性病与再生 • 上一篇    下一篇

阿尔茨海默病血液生物标志物:临床应用的关键挑战

  

  • 出版日期:2026-06-15 发布日期:2026-04-16

Blood biomarkers for Alzheimer's disease: key challenges of clinical implementation

Rafaela Luiza C. Franco, Tai R. Hunter, Fernanda G. De Felice*   

  1. D’Or Institute for Research and Education, Rio de Janeiro, Brazil (Franco RLC, De Felice FG)
    Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil (Franco RLC, De Felice FG)
    Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada (Hunter TR, De Felice FG)
    Center for Neuroscience Studies and Department of Psychiatry, Queen’s University, Kingston, ON, Canada (De Felice FG)
  • Online:2026-06-15 Published:2026-04-16
  • Contact: Fernanda G. De Felice, PhD, fernanda.defelice@queensu.ca.

摘要: https://orcid.org/0000-0001-8358-0589 (Fernanda G. De Felice)
 

Abstract: Alzheimer’s disease (AD) is a complex, progressive neurodegenerative disorder and the leading cause of dementia worldwide. It is characterized by the accumulation of extracellular amyloid–beta (Aβ) plaques and intracellular tau neurofibrillary tangles, leading to synaptic dysfunction, neuronal loss, and cognitive decline. These pathological changes can begin decades before clinical symptoms emerge, highlighting the critical need for early, accessible, and accurate diagnostic tools. Traditionally, AD diagnosis has relied on clinical assessments supported by neuroimaging and cerebrospinal fluid (CSF) biomarkers, which are accurate but costly and invasive (Jack et al., 2024). However, recent advancements in bloodbased biomarkers (BBMs) have opened a new frontier in AD diagnostics, offering a minimally invasive, cost-effective, and scalable approach to early detection and disease monitoring (Hunter et al., 2025). The 2024 Alzheimer’s Association guidelines mark a turning point by recognizing BBMs as core diagnostic tools alongside amyloid positron emission tomography (PET) imaging and CSF biomarkers (Jack et al., 2024). Here, we discuss the potential of BBMs in AD diagnosis, the technological advancements driving their development, and the key challenges that remain for their widespread clinical implementation.