1.The population of aged men is growing, together with their health care burden.
2.Testosterone production progressively falls in aging men and some studies associate low testosterone with the development of depression and impaired spatial ability.
3.Animal models link depression and spatial ability with hippocampal function and neurogenesis.
4.The degree to which low testosterone participates in the functional decline of these specific cognitive domains remains uncertain.
5.The merit of testosterone therapy for aged men is a contentious issue.
6.Further research is required to evaluate a causative relationship between age-related declines in hippocampal function, testosterone production and hippocampal neurogenesis.
7.New research may determine whether testosterone therapy could maintain hippocampal neurogenesis levels and thereby preserve hippocampal function in aging men.
1.老年人数增多,老年人的健康问题越来越突出。
2.老年男性的雄性激素水平下降与老年男性的抑郁及部分空间能力缺失相关。
3.抑郁及部分空间能力缺失与海马功能及神经发生相关。
4.睾酮导致老年男性的抑郁及部分空间能力缺失的剂量尚不明确。
5.睾酮治疗老年男性的抑郁及部分空间能力缺失的研究存有争议。
6.老年男性的海马功能,睾酮水平与海马神经发生的关系需进一步明确。
7.睾酮治疗是否能维持老年男性海马神经发生进而保持海马功能需要进一步验证。